Detection Cartridges, Modules, Systems and Methods
First Claim
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1. A detection cartridge comprising:
- a housing comprising an interior volume;
a sensor operably attached to the housing, the sensor comprising a detection surface;
a detection chamber located within the interior volume of the housing, wherein the detection chamber comprises a volume defined by the detection surface and an opposing surface spaced apart from and facing the detection surface, wherein the opposing surface comprises a flow front control feature; and
a waste chamber located within the interior volume of the housing, the waste chamber in fluid communication with the detection chamber.
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Abstract
Detection cartridges and associated components, as well as methods of using the same that provide sample materials to a sensor for detection are disclosed. Among the components that may be used in connection with the detection cartridges of the present invention are, e.g., input modules, fluid flow front control features, and volumetric flow rate control features. The modules may include one or more chambers containing different constituents for mixing and/or delivery into a detection cartridge.
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Citations
40 Claims
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1. A detection cartridge comprising:
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a housing comprising an interior volume;
a sensor operably attached to the housing, the sensor comprising a detection surface;
a detection chamber located within the interior volume of the housing, wherein the detection chamber comprises a volume defined by the detection surface and an opposing surface spaced apart from and facing the detection surface, wherein the opposing surface comprises a flow front control feature; and
a waste chamber located within the interior volume of the housing, the waste chamber in fluid communication with the detection chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 21, 22, 23, 24, 25, 26)
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17. A detection cartridge comprising:
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a housing comprising an interior volume;
a sensor operably attached to the housing, the sensor comprising surface acoustic wave acousto-mechanical sensor;
a detection chamber located within the interior volume of the housing, wherein the detection chamber comprises a volume defined by the detection surface and an opposing surface spaced apart from and facing the detection surface, wherein the opposing surface comprises one or more channels formed therein;
a waste chamber located within the interior volume of the housing, the waste chamber in fluid communication with the detection chamber;
absorbent material located within the waste chamber; and
capillary structure located between the detection chamber and the waste chamber.
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18. A detection cartridge comprising:
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a cartridge housing comprising an interior volume;
a sensor operably attached to the cartridge housing, the sensor comprising a detection surface;
a detection chamber located within the interior volume of the cartridge housing, wherein the detection chamber comprises a volume defined by the detection surface and an opposing surface spaced apart from and facing the detection surface, wherein the opposing surface comprises a flow front control feature;
a waste chamber located within the interior volume of the cartridge housing, the waste chamber in fluid communication with the detection chamber;
one or more sealed modules, wherein each module of the one or more sealed modules comprises an exit port attached to the cartridge housing through one or more module ports that open into the interior volume of the cartridge housing, and wherein each module further comprises;
a module housing comprising an exit port and a sealed interior volume;
an exit seal located over the exit port of the module; and
a plunger located within the interior volume of the module housing, wherein the plunger is movable from a loaded position in which the plunger is distal from the exit port to an unloaded position in which the plunger is proximate the exit port;
wherein movement of the plunger towards the exit port opens the exit seal such that material from the interior volume of the module housing exits through the exit port into the interior volume of the cartridge housing. - View Dependent Claims (19, 20)
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27. A sealed module comprising:
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a housing comprising an exit port and a sealed interior volume;
an exit seal located over the exit port;
a first chamber located within the interior volume of the housing, the first chamber comprising a liquid located therein;
a second chamber located within the interior volume of the housing, the second chamber comprising a reagent located therein;
an inter-chamber seal isolating the second chamber from the first chamber within the housing; and
a plunger, wherein the first chamber, the inter-chamber seal, the second chamber, and the exit seal are located between the plunger and the exit port, and wherein the plunger is movable from a loaded position in which the plunger is distal from the exit port to an unloaded position in which the plunger is proximate the exit port;
wherein movement of the plunger towards the exit port opens the inter-chamber seal such that the liquid in the first chamber contacts the reagent in the second chamber, and wherein further movement of the plunger into the unloaded position opens the exit seal such that the liquid and the reagent from the interior volume of the housing exit through the exit port. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A module comprising:
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a housing comprising an exit port and a sealed interior volume;
an exit seal located over the exit port;
a chamber located within the interior volume of the housing, the chamber comprising one or more reagents located therein;
a plunger movable from a loaded position in which the plunger is distal from the exit port to an unloaded position in which the plunger is proximate the exit port; and
an input port in fluid communication with the chamber, wherein the input port enters the chamber between the plunger and the exit port when the plunger is in the loaded position;
wherein movement of the plunger towards the exit port opens the exit seal such that material from the interior volume of the housing exits through the exit port. - View Dependent Claims (36, 37, 38, 39, 40)
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Specification