Systems and Methods Using Multiple Solvents for the Removal of Lipids from Fluids
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Abstract
This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
98 Citations
90 Claims
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1-70. -70. (canceled)
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71. A system for removing lipids from a fluid containing lipids or lipid-containing organisms, the system comprising:
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a first extraction solvent source;
a vortexer coupled to the first extraction solvent source and configured to receive the fluid and a first extraction solvent from the first extraction solvent source to form a first mixture and dissolve at least a portion of the lipids;
a centrifuge coupled to the vortexer and configured to receive the first mixture from the vortexer;
a second extraction solvent source;
a first solvent removal device coupled to the second extraction solvent source and the centrifuge and configured to receive at least a portion of the first mixture from the centrifuge and the second extraction solvent from the second extraction solvent source to form a second mixture and dissolve at least a portion of the first extraction solvent; and
a second solvent removal device coupled to the first solvent removal device and configured to receive the second mixture and remove at least a portion of any remaining solvents from the second mixture. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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85. A method for removing lipids from a fluid containing lipids or from lipid-containing organisms, the method comprising:
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supplying a first extraction solvent from a first extraction solvent source;
mixing the fluid and the first extraction solvent in a vortexer to form a first mixture;
passing the first mixture to a centrifuge;
spinning the first mixture;
passing at least a portion of the first mixture to a first solvent removal device;
supplying a second extraction solvent from a second extraction solvent source;
mixing the portion of the first mixture and a second extraction solvent to form a second mixture; and
passing the second mixture to a second solvent removal device. - View Dependent Claims (86, 87, 88, 89, 90)
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Specification