ASYMMETRIC MEMBRANES FOR DRUG DELIVERY DEVICES
First Claim
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1. A dosage form comprising a core containing at least one pharmaceutically active ingredient and which comprises at least one asymmetric membrane technology coating wherein said coating comprises:
- one or more substantially water-insoluble polymers, andone or more solid, water-soluble polymeric materials that do not contain amounts of hydrogen peroxide or formaldehyde greater than about 0.01% w;
w after storage at 40°
C./75% RH for 12 weeks.
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Abstract
The present invention provides an osmotic dosage form comprising a core containing at least one pharmaceutically active ingredient and which also comprises at least one asymmetric membrane coating wherein said coating comprises one or more substantially water-insoluble polymers, and, one or more solid, water-soluble polymeric materials that do not generate significant amounts of hydrogen peroxide or formaldehyde in long term storage.
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Citations
14 Claims
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1. A dosage form comprising a core containing at least one pharmaceutically active ingredient and which comprises at least one asymmetric membrane technology coating wherein said coating comprises:
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one or more substantially water-insoluble polymers, and one or more solid, water-soluble polymeric materials that do not contain amounts of hydrogen peroxide or formaldehyde greater than about 0.01% w;
w after storage at 40°
C./75% RH for 12 weeks. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of treatment for nicotine dependency, addiction and withdrawal, in particular for use in smoking cessation therapy, comprising the administration of one tablet daily of a dosage form comprising a core containing varenicline, or a pharmaceutically acceptable salt thereof, and an asymmetric membrane technology coating containing cellulose acetate and hydroxypropylcellulose.
Specification