Vaccine And Nucleic Acids Capable Of Protecting Poultry Against Colonisation By Campylobacter
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Abstract
Nucleic acids encoding Campylobacter proteins, in particular antigenic proteins such as a flagellin, or encoding a variant thereof, or a fragment of either of these, are capable of protecting poultry such as chickens, against colonisation by Campylobacter, and so may be used in veterinary therapy or prophylaxis. This has an impact on human health.
43 Citations
41 Claims
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1-21. -21. (canceled)
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22. A composition comprising;
an isolated nucleic acid encoding a Campylobacter protein, a nucleic acid encoding a variant thereof, or a fragment of either of these, wherein said nucleic acid is capable of protecting poultry against colonisation by Campylobacter. - View Dependent Claims (23, 24, 25, 26, 27, 28)
- 29. An isolated DNA the nucleotide sequence of which comprises SEQ ID NO. 2 or variants of SEQ ID No:
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33. A composition comprising;
an isolated nucleic acid encoding a Campylobacter protein selected from SEQ ID 1, SEQ ID 3, SEQ ID 4, SEQ ID 5, SEQ ID 6, SEQ ID 7, SEQ ID 8, SEQ ID 9, SEQ ID 10, SEQ ID 11, SEQ ID 12, SEQ ID 13, SEQ ID 14, SEQ ID 15, SEQ ID 16, SEQ ID 17, SEQ ID 18, SEQ ID 19, SEQ ID 20, or SEQ ID 21, a nucleic acid encoding a variant thereof, or a fragment of either of these and a veterinarily acceptable carrier. - View Dependent Claims (34, 35)
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36. A method of protecting poultry from colonisation by Campylobacter, said method comprising;
administering to the poultry an isolated nucleic acid encoding a Campylobacter protein selected from SEQ ID 1, SEQ ID 3, SEQ ID 4, SEQ ID 5, SEQ ID 6, SEQ ID 7, SEQ ID 8, SEQ ID 9, SEQ ID 10, SEQ ID 11, SEQ ID 12, SEQ ID 13, SEQ ID 14, SEQ ID 15, SEQ ID 16, SEQ ID 17, SEQ ID 18, SEQ ID 19, SEQ ID 20, or SEQ ID 21, a nucleic acid encoding a variant thereof, or a fragment of either of these. - View Dependent Claims (37, 38)
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40. A method of protecting a human from Campylobacter infection, said method comprising;
administering to poultry an isolated nucleic acid encoding a Campylobacter protein selected from SEQ ID 1, SEQ ID 3, SEQ ID 4, SEQ ID 5, SEQ ID 6, SEQ ID 7, SEQ ID 8, SEQ ID 9, SEQ ID 10, SEQ ID 11, SEQ ID 12, SEQ ID 13, SEQ ID 14, SEQ ID 15, SEQ ID 16, SEQ ID 17, SEQ ID 18, SEQ ID 19, SEQ ID 20, or SEQ ID 21, a nucleic acid encoding a variant thereof, or a fragment of either of these and a veterinarily acceptable carrier. - View Dependent Claims (41)
Specification