METHOD AND APPARATUS FOR DETECTING BIOMOLECULAR INTERACTIONS
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Abstract
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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Citations
40 Claims
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1-33. -33. (canceled)
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34. An instrument for detecting radiation from a surface of a biosensor having a surface grating structure, wherein a sample to be tested is placed on the surface grating structure, comprising:
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a broadband light source;
an optical system directing collimated light from the broadband light source to the surface of the biosensor so as to illuminate the surface;
apparatus detecting radiation from the biosensor in response to the illumination from the optical system, and a processing unit coupled to the detection apparatus programmed to derive a peak wavelength value of the detected radiation. - View Dependent Claims (35, 36, 37, 38, 39, 40)
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Specification