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Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation

  • US 20070253913A1
  • Filed: 03/13/2007
  • Published: 11/01/2007
  • Est. Priority Date: 09/10/2003
  • Status: Abandoned Application
First Claim
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1. A surfactant and excipient free pharmaceutical aerosol formulation for delivery by inhalation, said aerosol formulation consisting essentially of:

  • (i) a particulate powdered medicament produced by a supercritical fluid process, said particulate powdered medicament having a mass mean aerodynamic diameter of 5 microns or less and being dihydroergotamine; and

    (ii) at least one hydrofluoralkane propellant, such that the formulation has a respirable fraction of 40% or greater.

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