Pharmaceutical removal of vascular extensions from a degenerating disc

• US 20070253960A1
• Filed: 04/28/2006
• Published: 11/01/2007
• Est. Priority Date: 04/28/2006
• Status: Abandoned Application

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Roy, Josee, Drapeau, Susan, Marx, Jeffrey
• Application Number:
  US11/413,346
• Publication Number:
  US 20070253960A1
• Time in Patent Office: Days
• US Class Current: 424/143.100
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 38/179 for growth factors; for growth regulators
• CPC Class Codes: A61K 38/18 Growth factors; Growth regulators

Abstract

The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disc includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disc. Disruption of vascular elements includes causing the vascular extensions to retract from the disc, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

Claims

1. A method for treating neck or back pain with or without radiculopathy comprising providing an effective amount of a therapeutic agent to a disc region comprising a disc, the therapeutic agent adapted to disrupt a vascular element in the disc region.

2. The method of claim 1, wherein the disc is a degenerated disc.

3. The method of claim 1, wherein the therapeutic agent comprises an anti-angiogenic agent.

4. The method of claim 1, wherein the therapeutic agent is adapted to modulate at least one growth factor or cytokine, or the response of the vascular element to at least one growth factor or cytokine.

5. The method of claim 4, wherein the growth factor or cytokine is selected from a set consisting of vascular growth factor, fibroblast-growth factor, angiopoietins, pigment epithelium-derived factor and α

-IFN.

6. The method of claim 5, wherein the therapeutic agent comprises an inhibitory antibody, aptamer, or a soluble fragment of a growth factor or growth factor receptor.

7. The method of claim 6, wherein the therapeutic agent comprises bevacizumab, pegaptanib or ranibizumab.

8. The method of claim 1, wherein the therapeutic agent comprises an anti-angiogenic steroid or an angiostatic steroid.

9. The method of claim 8, wherein the therapeutic agent comprises anecortave acetate or triamcinolone acetonide.

10. The method of claim 1, wherein the therapeutic agent is adapted to modulate at least one extra-cellular matrix component or the response of the vascular element to at least one extra-cellular matrix component.

11. The method of claim 10, wherein the therapeutic agent is an MMP inhibitor.

12. The method of claim 11, wherein the MMP inhibitor is marimastat.

13. The method of claim 10, wherein the extra-cellular matrix component is a cell adhesion molecule.

14. The method of claim 13, wherein the cell adhesion molecule is selected from a set consisting of cadherins and integrins.

15. The method of claim 1, wherein the therapeutic agent is adapted to modulate a cytoskeletal component of the vascular element.

16. The method of claim 15, wherein the therapeutic agent targets microtubules.

17. The method of claim 16, wherein the therapeutic agent comprises combretastatin, vinca alkaloid or placlitaxel.

18. The method of claim 17, wherein the therapeutic agent is adapted to block the modulation of vascular elements by a pro-inflammatory molecule.

19. The method of claim 18, wherein the pro-inflammatory molecule is selected from a set consisting of cytokines, chemokines, neuropeptides, bradykinin, histamine and prostaglandins.