Contraceptive and Acne Medication Combination and Treatment of Acne and Other Diseases with Reduced Side Effects
First Claim
1. An improved method of treating acne comprising providing a blister pack comprising at least about 28 separate daily dosage units of a therapeutically effective amount of isotretinoin or other retinoic acid derivative equivalent, and at least about 21-28 additional daily dosage units of an oral contraceptive in a contraceptively effective amount selected from the group consisting of:
- estrogen, estrogen and progestogen, mifepristone, or a combination thereof, whereby for at least about 21 successive days, said oral dosage unit of isotretinoin or other retinoic acid derivative equivalent and said oral dosage unit of said oral contraceptive are administered to a female of child bearing age.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides pharmaceutical compositions for the treatment of acne, psychotic illnesses, such as schizophrenia, cancer, such as cancer of the head, neck and lung, and emphysema, comprising co-administering a therapeutically effective amount of isotretinoin and a contraceptive in a contraceptively effective dosage. The contraceptive preferably does not contain 100 wt % progestogen. Methods of treating acne and unit dosage delivery systems are also provided. Also provided is an improved method of treating acne, and other diseases, comprising providing a blister pack comprising at least about 28 separate daily dosage units of a therapeutically effective amount of isotretinoin, or other retinoic acid derivative equivalent, and at least about 21-28 additional daily dosage units of an oral contraceptive in a contraceptively effective amount, selected from the group consisting essentially of: estrogen, estrogen and progestogen, mifepristone, or a combination thereof, whereby for at least about 21 successive days, said oral dosage unit of isotretinoin, or other retinoic acid derivative equivalent, and said oral dosage unit of said oral contraceptive are administered to a female of child-bearing age. Patch, inhaler, nebulizer, and injection formulations for the preferred active ingredients are also provided.
-
Citations
33 Claims
-
1. An improved method of treating acne comprising providing a blister pack comprising at least about 28 separate daily dosage units of a therapeutically effective amount of isotretinoin or other retinoic acid derivative equivalent, and at least about 21-28 additional daily dosage units of an oral contraceptive in a contraceptively effective amount selected from the group consisting of:
- estrogen, estrogen and progestogen, mifepristone, or a combination thereof, whereby for at least about 21 successive days, said oral dosage unit of isotretinoin or other retinoic acid derivative equivalent and said oral dosage unit of said oral contraceptive are administered to a female of child bearing age.
- View Dependent Claims (2, 3, 4, 5, 6)
-
7. A pharmaceutical blister pack having dosage units arranged sequentially and comprising:
-
a first phase comprising at least about 21 daily dosage units of an oral contraceptive, and at least about 21 daily dosage units of isotretinoin or other retinoic acid derivative equivalent; and a second phase of about 4-8 daily dosage units of isotretinoin or other retinoic acid derivative equivalent. - View Dependent Claims (8, 9)
-
- 10. A pharmaceutical packaging comprising dosage units arranged sequentially and comprising a first phase comprising 21 separate daily dosage units of an oral contraceptive which do not contain 100% progestogen, and at least about 21 separate daily dosage units of isotretinoin, or other retinoic acid derivative equivalent, and a second phase comprising at least about 4-8 separate daily dosage units of isotretinoin, or other retinoic acid derivative equivalent.
- 12. A pharmaceutical packaging comprising dosage units arranged sequentially and comprising a first phase comprising 21-28 separate daily dosage units of an oral contraceptive in a contraceptively effective amount, which does not contain 100% progestogen, and at least about 21-56 separate daily dosage units of isotretinoin, or other retinoic acid derivative equivalent, in a therapeutically effective amount.
- 15. A pharmaceutical packaging comprising dosage units arranged sequentially and comprising a first phase comprising 21 separate dosage units of an oral contraceptive in a contraceptively effective amount which do not contain 100% progestogen, in admixture, with isotretinoin, or other retinoic acid derivative equivalent, in a therapeutically effective amount, and a second phase comprising at least about 4-8 separate dosage units of isotretinoin or other retinoic acid derivative equivalent in a therapeutically effective amount.
- 17. A pharmaceutical packaging comprising dosage units arranged sequentially and comprising a first phase comprising 21 separate dosage units of an oral contraceptive in a contraceptively effective amount which does not contain 100% progestogen, and at least about 21 separate dosages units of isotretinoin, or other retinoic acid derivative equivalent, in a therapeutically effective amount, and a second phase comprising at least about 4-8 separate dosage units of isotretinoin, or other retinoic acid derivative equivalent, in a therapeutically effective amount, without oral contraceptive administration.
- 19. A method of treating acne comprising providing a transdermal patch comprising a therapeutically effective amount of isotretinoin or other retinoic acid derivative equivalent in a therapeutically effective amount and a transdermal contraceptive in a contraceptively effective amount.
-
22. A medicated transdermal patch comprising,
a time released drug formulation comprising a therapeutically effective amount of isotretinoin or other retinoic acid derivative equivalent and a transdermal contraceptive in a contraceptively effective amount.
- 28. A method of treating or preventing emphysema in a patient comprising co-administering a therapeutically effective amount of isotretinoin and a contraceptively effective dosage of a contraceptive.
- 30. A method of treating or preventing psychotic illness in a patient comprising co-administering a therapeutically effective amount of isotretinoin and a contraceptively effective dosage of a contraceptive.
- 32. A method of treating or preventing cancer in a patient comprising co-administering a therapeutically effective amount of isotretinoin and a contraceptively effective dosage of a contraceptive.
Specification