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OLIGONUCLEOTIDE SYNTHESIS WITH INTERMITTENT AND POST SYNTHETIC OXIDATION

  • US 20070255054A1
  • Filed: 01/02/2007
  • Published: 11/01/2007
  • Est. Priority Date: 12/30/2005
  • Status: Abandoned Application
First Claim
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1. A process for fabricating an array of polymers on a solid support, comprising the steps of:

  • (a) coupling a monomer with a reactive site masked by a protecting group to a growing polymer chain;

    (b) optionally capping the monomer or monomer chains that have not reacted in a giving cycle;

    (c) deprotecting the product with a deprotecting agent;

    (d) repeating steps (a)-(c) on regions of support as necessary to give a polymers having a desired sequence and length; and

    (e) oxidizing the intermonomer linkages post-synthetically.

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