System and method for in vivo imager with stabilizer

• US 20070255098A1
• Filed: 01/19/2007
• Published: 11/01/2007
• Est. Priority Date: 01/19/2006
• Status: Abandoned Application

• Current Assignee: CapsoVision, Inc.
• Original Assignee: CapsoVision, Inc.
• Inventors: Wilson, Gordon, Wang, Kang-Huai
• Application Number:
  US11/655,640
• Publication Number:
  US 20070255098A1
• Time in Patent Office: Days
• US Class Current: 600/109
• CPC Class Codes: A61B 1/00177 for 90 degrees side-viewing
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/06 with illuminating arrangements
• CPC Class Codes: A61B 1/0615 for radial illumination
• CPC Class Codes: A61B 1/0684 using light emitting diodes [LED]

Abstract

A swallowable capsule with a camera and a memory for imaging the colon. Standard semiconductor memory (memories made of standard memories processes or processes modified from standard process by adopting comprehensible silicon planar technology process steps) is used. This is made possible by the use of an optimal type of image compression that can be performed with limited processing power and limited memory (e.g., without requiring a full size frame buffer). Also, controls on the number of images taken are used in one embodiment.

Claims

1. An in vivo camera system comprising:

a capsule having a stabilizing mechanism configured to orient the capsule in a consistent orientation relative to an internal organ; and

a panoramic imager encased within the capsule and configured with a field of view that includes substantially all directions perpendicular to the principle direction of in vivo camera system travel for capturing a peripheral image of tissue surface surrounding the capsule on a single image plane.

2. An in vivo camera system according to claim 1, wherein the imager is a plurality of cameras encased within the capsule and configured to capture a plurality of images of tissue surrounding the capsule on a single image plane.

3. An in vivo camera system according to claim 1, further comprising a cover that covers the stabilizing mechanism prior to deployment.

4. An in vivo camera system according to claim 3 where the cover is soluble in the gastro intestinal tract.

5. An in vivo camera system according to claim 3 where the cover is pushed off the stabilizing mechanism by a force applied by the stabilizing mechanism.

6. An in vivo camera system comprising:

a capsule having at least one balloon configured to inflate and orient the capsule in a consistent orientation relative to an internal organ wherein, upon inflation, the overall length of the in vivo camera system, in a direction substantially parallel to the predominant direction of camera motion, is increased; and

an imager encased within the capsule.

7. An in vivo camera system according to claim 6, wherein the imager is a panoramic imager encased within the capsule and configured with a field of view that includes substantially all directions perpendicular to a subject tissue surface for capturing a peripheral image of tissue surface surrounding the capsule on a single image plane.

8. An in vivo camera system according to claim 6 wherein the at least one balloon is covered by a cover prior to inflation.

9. An in vivo camera system according to claim 8 wherein the cover is soluble in the gastro intestinal tract.

10. An in vivo camera system according to claim 8 wherein the cover is pushed off at least one balloon by the force of its inflation.

11. An in vivo camera system according to claim 6 wherein at least one balloon attaches directly to the capsule body.

12. An in vivo camera system according to claim 6, wherein balloons are configured to expand at two or more separate locations on the capsule to stabilize the orientation of the capsule while traveling through the organ.

13. An in vivo camera system according to claim 6, wherein balloons are configured to expand at two ends of the capsule to stabilize the orientation of the capsule while moving though a colon.

14. An in vivo camera system according to claim 6, wherein the capsule is configured to capture images while traveling through a gastrointestinal track, where the in vivo camera system operates in a first confined mode while traveling through the small intestine and in a second expanded mode while subsequently traveling through the colon, wherein the at least one balloon is configured to expand, when activated by the occurrence of at least one event, to stabilize the orientation of the capsule while moving though the colon.

15. An in vivo camera system according to claim 6, wherein the at least one balloon inflates using a phase transition that is activated upon the occurrence of at least one event to expand the at least one balloon and to stabilize the orientation of the capsule while moving through an organ.

16. An in vivo camera system according to claim 15, wherein prior to inflation the system contains a liquid or solution of liquids such that the total vapor pressure of the liquid or solution is substantially equal to a predetermined value, such that the balloon pressure upon inflation with vapor will not exceed this predetermined value.

17. An in vivo camera system according to claim 14, wherein an event includes detection of entrance into the colon.

18. An in vivo camera system according to claim 14, wherein an event includes the expiration of a predetermined amount of time.

19. An in vivo camera system according to claim 14, wherein an event includes the reception of a remote actuation signal.

20. An in vivo camera system according to claim 6, further comprising at least one reserve configured to store an expandable gas and a balloon actuator configured to release the expandable gas from the reserve and into the at least one balloon.

21. An in vivo camera system according to claim 15, further comprising at least one reserve configured to store a mixture of substances that is at least partially in the liquid state, wherein the balloon actuator is configured to release at least one substance from the reserve into the at least one balloon, wherein at least a portion of the substance released vaporizes.

22. An in vivo camera system according to claim 6, further comprising a release valve configured to actuate when a predetermined balloon pressure is detected to deflate the at least one balloon upon the occurrence of the predetermined pressure.

23. An in vivo camera system according to claim 6, further comprising a release valve configured to actuate when the motion detector determines that the capsule has not progressed significantly for a predetermined period of time.

25. An in vivo camera system according to claim 6, further comprising a release valve configured to actuate and deflate the at least one balloon when the motion detector determines that the capsule has not progressed, or over the course of some number of sequential image captures when the capsule is impeded from movement.

26. An in vivo camera system according to claim 6, wherein the at least one balloon is configured to inflate using a chemical reaction to expand the at least one balloon and to stabilize the orientation of the capsule while moving though an organ.

27. An in vivo camera system according to claim 26, wherein the chemical reaction is triggered by the mixing of two or more chemicals.

28. An in vivo camera system according to claim 26 wherein the chemical reaction is triggered by the heating of one or more chemicals.

29. An in vivo camera system according to claim 26, wherein the chemical reaction is triggered by passing an electrical current through one or more chemicals.

24. An in vivo camera system according to claim C6, further comprising a release valve configured to actuate and deflate the at least one balloon when the motion detector determines that the capsule has not progressed significantly over the course of some number of sequential image captures.

30. A method for in-vivo imaging, comprising:

providing a device having a stabilization mechanism for stable panoramic in-vivo imaging of an internal organ onto a single image plane;

guiding the device within an organ using the stabilization mechanism;

emitting electromagnetic radiation in the wavelength range from the device; and

receiving reflections of the electromagnetic radiation from tissue surfaces for use in forming a panoramic image of the tissues from a field of view that includes substantially all directions perpendicular to the principle direction of travel.

32. A method according to claim 30, wherein receiving reflections includes receiving reflections from a field of view that includes substantially all directions perpendicular to the principle direction of travel.

33. A method according to claim 30, further comprising

uploading image data to a host computer.

34. A method according to claim 30, further comprising:

performing compression on images detected by an image sensor to produce compressed image data; and

uploading the compressed image data to a host computer.

37. A method according to claim 30, further comprising:

initiating an actuator upon the occurrence of at least one event;

inflating stabilizing balloons at least two separate locations on the device by the actuator in response to initiation to stabilize the orientation of the device while moving within the organ.

39. A method according to claim 37, wherein an event includes a predetermined period of time.

40. A method according to claim 37, wherein an event includes a predetermined period of time that is calculated to enable inflation of the balloons when the capsule enters a subject'"'"'s colon.

41. A method according to claim 37, wherein the event is the reception of a remote actuator signal.

42. A method according to claim 37, wherein the event is the detection of a decrease in the fraction of illuminating light energy reflected from outside the capsule back into the capsule.

43. A method according to claim 42 wherein the detection is made by the image sensor.

44. A method according to claim 42 wherein the detection is made by a photodiode.

45. A method according to claim 42 wherein the illuminating light energy is derived from LED driving current.

46. A method according to claim 37, wherein the event is multiple occurrences of the predetermined conditions.

48. A method according to claim 37, wherein the event is a detection by a PH meter that the capsule is within the colon.

49. A method according to claim 48, wherein the event is a detection by a PH meter the PH values fit a specific pattern that the capsule is within the colon.

50. A method according to claim 49, wherein an event includes multiple occurrences of the conditions.

51. A method according to claim 37, wherein an event includes a detection by an image processor that the capsule is within the colon.

52. A method according to claim 51 wherein the image processor determines the distance from the capsule to the lumen wall in at least one direction by determining the amount of overlap in at least a portion of two images captured by two cameras with overlapping fields of view.

53. A method according to claim 51 wherein the image processor determines the distance from the capsule to the lumen wall in at least one direction by determining the amount of overlap in at least a portion of at least two images captured by the same camera at two or more different times.

55. A method according to claim 30, further comprising:

inflating at least one balloon using a phase transition to expand the balloons, stabilizing the orientation of the device while moving within the organ.

31. Deploying the stabilization mechanism

35. A method for in-vivo imaging, comprising:

providing a device having at least one balloon for stable in-vivo imaging of an internal organ inflating the at least one balloon upon the occurrence of at least one event, wherein the overall length of the device, in a direction substantially parallel to the principle direction of camera motion, is increased;

guiding the device within an organ using the stabilization mechanism;

emitting electromagnetic radiation in the wavelength range from the device; and

receiving reflections of the electromagnetic radiation from tissue surfaces for use in forming an image of the tissues.

36. A method according to claim 35, further comprising:

inflating balloons at least two separate locations on the device to stabilize the orientation of the device while moving within the organ.

54. A method according to claim 35, further comprising:

inflating at least one balloon using a compressed gas to expand the balloons, stabilizing the orientation of the device while moving within the organ.

56. A method according to claim 35, further comprising:

deflating the at least one balloon to reduce the size of the device.

57. A method according to claim 56, further comprising:

deflating the at least one balloon in response to a change in pressure.

58. A method according to claim 56, further comprising:

deflating the at least one balloon in response to the expiration of a predetermined period of time.

59. A method according to claim 56, further comprising:

deflating the at least one balloon in response to the detection by the capsule of a lack of movement of the capsule relative to a subject tissue.

38.

47.