Noninvasive glucose sensing methods and systems

• US 20070255141A1
• Filed: 01/22/2007
• Published: 11/01/2007
• Est. Priority Date: 01/20/2006
• Status: Active Grant

• Current Assignee: Donald Prough, Rinat Esenaliev
• Original Assignee: Donald Prough, Rinat Esenaliev
• Inventors: Esenaliev, Rinat, Prough, Donald
• Granted Patent: US 8,135,450 B2
• Time in Patent Office: Days
• US Class Current: 600/475
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/1075 for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer A61B8/0858 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.

Claims

1. A method for noninvasive glucose sensing including the steps of:

measuring a thickness of a target tissue and

determining a glucose value from the thickness of the target tissue in accordance with a target tissue thickness calibration curve.

2. A method for noninvasive glucose sensing including the steps of:

measuring a time of flight of ultrasound or optical pulses in a target tissue and

determining a glucose value from the time of flight in the target tissue in accordance with a time of flight versus glucose calibration curve.