Method of Treatment for Undesired Effect Following Transdermal or Topical Drug Delivery
First Claim
1. A method for inhibiting the percutaneous absorption of a physiologically active agent topically applied to a transdermal administration site of a subject, the method including the step of applying to skin of the subject at the transdermal administration site, a device comprising a membrane for contacting the skin of the subject coated on the skin contacting side thereof with a layer of an adhesive.
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Abstract
This invention relates to a method for inhibiting the percutaneous absorption of a physiologically active agent topically applied to a transdermal administration site of a subject, the method including the step of applying to skin of the subject at the transdermal administration site, a device (1, 7) comprising a membrane (8) for contacting the skin of the subject coated on the skin contacting side thereof (11) with a layer of an adhesive (10).
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19 Claims
- 1. A method for inhibiting the percutaneous absorption of a physiologically active agent topically applied to a transdermal administration site of a subject, the method including the step of applying to skin of the subject at the transdermal administration site, a device comprising a membrane for contacting the skin of the subject coated on the skin contacting side thereof with a layer of an adhesive.
- 5. A method for removal of physiologically active agent from the reservoir thereof within the skin of a subject following transdermal administration of the physiologically active agent to a site on the skin of the subject the method including the step of applying a device comprising a membrane to the site of transdermal administration of the pharmaceutically active agent.
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16. A method of reducing the effect of overdose via transdermal administration of a physiologically active agent to a site of skin of a subject to form a reservoir of physiologically active agent in the skin the method comprising providing a membrane assembly for contacting the site of skin the membrane assembly comprising (a) selectively permeable membrane for making contact with the skin to allow ingress of physiologically active agent and provided with an adhesive layer on the skin side thereof, (b) a backing layer and (c) a reservoir of solvent between the backing layer and membrane wherein the physiologically active agent is at least partly soluble in the solvent and preferably (d) a solvent impermeable layer adjacent the side of said membrane remote from the adhesive;
- and applying the adhesive layer of the membrane assembly to the site of transdermal administration wherein the physiologically active agent is extracted from the skin into the membrane assembly.
Specification