Substance Delivery Device

• US 20070255198A1
• Filed: 09/12/2005
• Published: 11/01/2007
• Est. Priority Date: 09/17/2004
• Status: Abandoned Application

• Current Assignee: pSiMedica Limited (EyePoint Pharmaceuticals, Inc.)
• Original Assignee: pSiMedica Limited (EyePoint Pharmaceuticals, Inc.)
• Inventors: Canham, Leigh, Leong, Weng
• Application Number:
  US11/663,056
• Publication Number:
  US 20070255198A1
• Time in Patent Office: Days
• US Class Current: 604/65
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001

Abstract

The present invention relates to a substance delivery device comprising: (a) an electronic component, (b) a carrier component, and (c) a beneficial substance, the electronic component comprising: (i) a timer means for generating a carrier activation electrical signal that is time dependent; (ii) an electronic carrier activation means for releasing the beneficial substance in response to the carrier activation electrical signal; (iii) a power supply; and (iv) a substance delivery device activation means, for activating the device, having a construction such that once the substance delivery device is activated the electronic carrier activation means releases the beneficial substance in response to the carrier activation electrical signal. The substance delivery device is of particular value in the treatment of circadian, infradian, or ultradian cycle conditions.

Claims

1. A substance delivery device comprising:

(a) an electronic timer means for generating a time dependent electronic signal, (b) a substance delivery device activation means for activating the substance delivery device, (c) a beneficial substance, and (d) a beneficial substance release means for releasing the beneficial substance in response to the time dependent electronic signal, once the substance delivery device has been activated.

2. A substance delivery device according to claim 1 characterised in that timer means, when in use, has a construction and/or has been programmed to generate an electronic signal having a periodic variation with time.

3. A substance delivery device according to claim 2 characterised in that the period of variation is selected from one or more of:

12 hours, 1 day, 2 days, 1 week, 2 weeks, and 1 month.

4. A substance delivery device according to claim 1 characterised in that the device activation means comprises an activation electrical switch having an on state and an off state, the substance delivery device having a construction such that, when in use, the beneficial substance release means releases the beneficial substance once the electrical switch is in an on state.

5. A substance delivery device according to claim 4 characterised in that the substance delivery device, and electrical activation means each have a construction such that, when the substance delivery device has been immersed in a physiological electrolyte, the activation electrical switch is switched to an on state by contact between the electrical activation means and the physiological electrolyte.

6. A substance delivery device according to claim 1 characterised in that the beneficial substance release means comprises porous silicon, the beneficial substance being located in at least some of the pores of the porous silicon.

7. A substance delivery device according to claim 6 characterised in that the beneficial substance release means further comprises two or more pH electrodes, and a means for applying a potential difference between the two, or at least two of, electrodes, the arrangement of the pH electrodes and potential difference being such that, when immersed in a physiological electrolyte, OH—

ions are attracted towards at least part of the porous silicon by the electrical field generated by the pH electrodes.

8. A substance delivery device according to claim 7 characterised in that the substance delivery device has a construction such that none of the pH electrodes is in direct physical contact with porous silicon.

9. A packaged substance delivery device comprising a package in which at least one substance delivery device, as claimed in claim 1, is disposed.

10. A packaged substance delivery device according to claim 9, characterised in that the or at least one of the device activation has a construction such that removal of the device from the package activates the delivery device.