Hemostatic Polymer Useful for Rapid Blood Coagulation and Hemostasis

• US 20070255238A1
• Filed: 04/05/2007
• Published: 11/01/2007
• Est. Priority Date: 11/12/1998
• Status: Abandoned Application

• Current Assignee: Craig E. Lighty, International Manufacturing Center
• Original Assignee: Craig E. Lighty
• Inventors: Cochrum, Kent, Gunther, Robert, Beninsig, Franklin, Jemtrud, Susan
• Application Number:
  US11/697,185
• Publication Number:
  US 20070255238A1
• Time in Patent Office: Days
• US Class Current: 604/290
• CPC Class Codes: A61F 13/01034 characterised by a property
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 13/8405 Additives, e.g. for odour, disinfectant or pH control
• CPC Class Codes: A61F 2013/00119 elastic
• CPC Class Codes: A61F 2013/00229 with alginate
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61F 2013/00931 chitin
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 26/0023 Polysaccharides
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/0076 Sprayable compositions
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

Provided herein is a novel hemostatic polymer composition comprising a substance containing uncharged organic hydroxyl groups and a substance containing at least one of a halogen atom and an epoxy group, which is characterized as inducing rapid blood coagulation and hemostasis at a wound or bleeding site. Methods of use of the novel polymer composition are also provided.

Claims

1. A method for promoting blood coagulation at a bleeding site in a mammal comprising applying to said bleeding site a dispersion comprising porous polymeric spheres and allowing said blood coagulation to occur at said bleeding site.

2. The method of claim 1, wherein said mammal is a human.

3. The method of claim 1, wherein said porous polymeric spheres comprise a carbohydrate, a polysaccharide, or a polyol.

4. The method of claim 3, wherein said polysaccharide comprises cross-linked dextran, cross-linked starch, cross-linked alginate, or cross-linked cellulose.

5. The method of claim 4, wherein said polysaccharide comprises cross-linked dextran.

6. The method of claim 1, wherein the carrier of said dispersion is a pharmaceutically acceptable carrier.

7. The method of claim 6, wherein said carrier comprises water, saline, phosphate buffered saline, or ethanol.

8. The method of claim 7, wherein said carrier is saline.

9. The method of claim 1, wherein said dispersion further comprises a preservative.

10. The method of claim 9, wherein said preservative comprises one or more antibacterial agents, antifungal agents, or mixtures thereof.

11. The method of claim 10, wherein said antibacterial and antifungal agents are selected from the group consisting of parabens, chlorobutanol, phenol, sorbic acid, and thimerosal.

12. The method of claim 6, wherein the carrier of said dispersion is saline.

13. The method of claim 12, wherein said dispersion comprises 0.1 grams of cross-linked dextran per 0.5 mL saline.

14. The method of claim 12, wherein said dispersion comprises 0.1 grams of cross-linked dextran per 1.0 mL of saline.

15. The method of claim 1, wherein said dispersion further comprises an additional hemostatic agent.

16. The method of claim 15, wherein said additional hemostatic agent is selected from collagen, thrombin, cationic poly-amino acids, fibrinogen, and blood clotting factors.

17. The method of claim 16, wherein said additional hemostatic agent is thrombin.