Threshold optimization for tissue stimulation therapy
First Claim
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1. A method, comprising:
- a) delivering an electrical signal to a cranial nerve of a patient according to at least a first parameter and a second parameter;
b) measuring an electrical response of said nerve to said electrical signal;
c) adjusting said first parameter while said second parameter remains constant; and
d) repeating a) through c) to acquire a plurality of electrical responses; and
e) determining a lower threshold setting and an upper threshold setting from the plurality of electrical responses.
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Abstract
Methods and systems for determining an optimal therapeutic window of parameter settings for nerve stimulation therapy are described herein. The disclosed techniques generally utilize one or more parameter sweeps to determine upper and lower threshold settings. The determination of the optimal therapeutic window may be performed during or after implantation.
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Citations
24 Claims
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1. A method, comprising:
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a) delivering an electrical signal to a cranial nerve of a patient according to at least a first parameter and a second parameter;
b) measuring an electrical response of said nerve to said electrical signal;
c) adjusting said first parameter while said second parameter remains constant; and
d) repeating a) through c) to acquire a plurality of electrical responses; and
e) determining a lower threshold setting and an upper threshold setting from the plurality of electrical responses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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a) delivering a plurality of electrical signals to a nerve of a patient at a plurality of current amplitudes and a constant pulse width;
b) recording a plurality of electrical responses of the nerve to the plurality of electrical signals; and
c) determining at least one lower threshold setting and at least one upper threshold setting from the plurality of electrical responses. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. A system, comprising:
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a processor;
software executable on said processor, wherein said software causes the processor to;
a) instruct an implantable medical device to deliver a plurality of electrical signals to a nerve according to at least first and second parameters, wherein said first parameter is iteratively adjusted while said second parameter remains fixed, b) detect a plurality of electrical responses of the nerve to said plurality of electrical signals, and c) determine a lower threshold setting and an upper threshold setting from said plurality of electrical responses based on said fixed second parameter. - View Dependent Claims (21, 22, 23, 24)
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Specification