Apparatus and method for treating cardiovascular diseases

• US 20070255389A1
• Filed: 04/26/2007
• Published: 11/01/2007
• Est. Priority Date: 04/26/2006
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Navia, Jose, Oberti, Carlos
• Granted Patent: US 9,114,035 B2
• Time in Patent Office: Days
• US Class Current: 623/1.110
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2250/003 differing in adsorbability or resorbability, i.e. in adsorption or resorption time
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy

Abstract

An apparatus for treating cardiovascular diseases includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions for positioning in a blood vessel. The proximal end portion of the expandable support member includes a plurality of wing members that extend from the main body portion. Each of the wing members is for engaging at least a portion of an antrum of a cardiac chamber surrounding the blood vessel. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue. The expandable support member is made of wire-mesh, and at least a portion of the expandable support member may be made of a bioabsorbable material.

Claims

1. An apparatus for treating cardiovascular diseases, said apparatus comprising:

an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between said end portions for positioning in a blood vessel, said proximal end portion of said expandable support member comprising a plurality of wing members that extend from said main body portion;

each of said wing members for engaging a portion of an antrum of a cardiac chamber surrounding the blood vessel; and

at least a portion of said expandable support member being treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue.

2. The apparatus of claim 1 wherein said main body portion is shaped for conforming to at least a portion of a blood vessel.

3. The apparatus of claim 1 wherein each of said wing members is shaped for conforming to the shape of the portion of an antrum of a cardiac chamber surrounding the blood vessel.

4. The apparatus of claim 1 wherein said wing members include an attachment mechanism for engaging the portion of an antrum of a cardiac chamber.

5. The apparatus of claim 4 wherein said attachment mechanism includes at least one hook member.

6. The apparatus of claim 5 wherein said hook members, when embedded into the portion of an antrum of a cardiac chamber, extend distally from said wing members.

7. The apparatus of claim 1 further comprising a layer of biocompatible material covering at least a portion of said expandable support member.

8. The apparatus of claim 1 wherein a plurality of portions of said expandable support member are separately treated with a different one of said at least one therapeutic agent.

9. The apparatus of claim 8 wherein said main body portion and said wing members are each separately treated with a different one of said at least one therapeutic agent.

10. The apparatus of claim 8 wherein each of said wing members is separately treated with a different one of said at least one therapeutic agent.

11. The apparatus of claim 1 wherein said expandable support member is comprised of wire-mesh.

12. The apparatus of claim 1 wherein at least a portion of said expandable support member is bioabsorbable.

13. The apparatus of claim 1 further comprising an inflatable balloon for expanding said expandable support member so that said expandable support member engages the at least a portion of the ostium of a blood vessel.

14. The apparatus of claim 1 further comprising a capsule for containing said expandable support member in a collapsed configuration, said capsule being removable to allow said expandable support member to expand into the at least a portion of the ostium of a blood vessel.

15. The apparatus of claim 1 further comprising an electrical mechanism for delivering electrical energy to the at least a portion of the ostium of a blood vessel.

16. A method for treating cardiovascular diseases, said method comprising the steps of:

providing an apparatus having an expandable support member, at least a portion of the expandable support member being treated with at least one therapeutic agent for eluting into a blood vessel, a cardiac chamber, and/or cardiac tissue;

inserting the expandable support member into a cardiac chamber;

advancing the expandable support member until the expandable support member is positioned within at least a portion of the ostium of a blood vessel;

expanding the expandable support member so that the expandable support member engages the at least a portion of the ostium of a blood vessel; and

securing the expandable support member in at least a portion of an antrum of a cardiac chamber.

17. The method of claim 16 wherein said expandable support member has oppositely disposed proximal and distal end portions connected by a main body portion, said step of expanding the expandable support member so that the expandable support member engages at least a portion of the ostium of a blood vessel further including the step of conforming the shape of the main body portion to the shape of a portion of a blood vessel to help locate and secure the expandable support member in the at least a portion of an antrum of a cardiac chamber.

18. The method of claim 17 wherein the proximal end portion of the expandable support member comprises a plurality of wing members that extend from the main body portion for securing the expandable support member in the at least a portion of an antrum of a cardiac chamber.

19. The method of claim 18 wherein the wing members include an attachment mechanism for engaging the at least a portion of an antrum of a cardiac chamber surrounding the blood vessel.

20. The method of claim 19 wherein the attachment mechanism includes at least one hook member.

21. The method of claim 18 wherein said method further includes the step of embedding the hook members into the at least part of the wall of a portion of an antrum of a cardiac chamber to further secure the expandable support member in the at least a portion of an antrum of the cardiac chamber.

22. The method of claim 16 wherein said step of inserting the expandable support member into the cardiac chamber is done percutaneously via an intravascular catheter.

23. The method of claim 16 wherein a plurality of portions of the expandable support member are separately treated with a different one of the at least one therapeutic agent.

24. The method of claim 23 wherein the main body portion and the wing members are each separately treated with a different one of the at least one therapeutic agent.

25. The method of claim 23 wherein each of the wing members is separately treated with a different one of the at least one therapeutic agent.

26. The method of claim 16 wherein the expandable support member is comprised of wire-mesh.

27. The method of claim 16 wherein at least a portion of the expandable support member is bioabsorbable.

28. The method of claim 16 wherein an expandable balloon is used to expand the expandable support member in the at least a portion of the ostium of a blood vessel.

29. The method of claim 16 wherein the expandable support member is delivered to the cardiac chamber via a catheter in a collapsed configuration, and then self-expands into the at least a portion of the ostium of a blood vessel once the catheter is removed.