NOISE REDUCTION FOR ANALYTE DETECTION SYSTEMS
First Claim
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1. A method for determining the concentration of an analyte in a sample, the method comprising:
- providing an optical detector signal from an optical detector, the signal having information relating to the concentration of an analyte in a sample;
passing the optical detector signal through a first demodulator;
providing a vibration sensor signal, the vibration signal having information relating to the vibration of the optical detector;
passing the vibration sensor signal through a second demodulator;
providing a threshold value for the vibration sensor signal that is calculated to correspond to an accuracy parameter of a system concentration output; and
controlling measurement by the optical detector based on whether or not the threshold value is exceeded.
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Abstract
Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. Some embodiments use a synchronous demodulator and digital filter to reduce microphonic signal content. Some embodiments monitor the microphonic signal content and “hold off” on making a measurement until vibrations subside. Monitoring can be performed using an accelerometer or other vibration sensor. An algorithm can be used to examine the detector output signal and detect excessive microphonic components, making an accelerometer unnecessary.
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Citations
28 Claims
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1. A method for determining the concentration of an analyte in a sample, the method comprising:
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providing an optical detector signal from an optical detector, the signal having information relating to the concentration of an analyte in a sample;
passing the optical detector signal through a first demodulator;
providing a vibration sensor signal, the vibration signal having information relating to the vibration of the optical detector;
passing the vibration sensor signal through a second demodulator;
providing a threshold value for the vibration sensor signal that is calculated to correspond to an accuracy parameter of a system concentration output; and
controlling measurement by the optical detector based on whether or not the threshold value is exceeded. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for improving accuracy of a mobile analyte concentration measurement apparatus, the system comprising:
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a sample detector configured to provide a detector output signal;
a first signal conditioner configured to receive the detector output signal;
a vibration sensor mounted to detect vibration of the sample detector and configured to provide a sensor output signal;
a second signal conditioner configured to receive the sensor output signal; and
a controller configured to communicate with the sample detector and the vibration sensor and prevent the sample detector from detecting when the sensor output signal exceeds a threshold value. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of mitigating the effects of vibration on an optical analyte detection system measurements, the method comprising:
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monitoring microphonic effects to determine when a threshold is exceeded; and
automatically delaying optical measurement until after the threshold is no longer exceeded. - View Dependent Claims (26, 27, 28)
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Specification