Method of producing high alcohol content foaming compositions with silicone-based surfactants

• US 20070258911A1
• Filed: 06/04/2007
• Published: 11/08/2007
• Est. Priority Date: 03/07/2005
• Status: Active Grant

• Current Assignee: DEB IP Limited (SC Johnson & Son Incorporated)
• Original Assignee: DEB Worldwide Healthcare Incorporated
• Inventors: Fernandez de Castro, Maria, Kolvisto, Bruce, Munoz, Francisco
• Granted Patent: US 8,313,758 B2
• Time in Patent Office: Days
• US Class Current: 424/47
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/06 Aerosols
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: B65D 83/00 Containers or packages with special means for dispensing contents dispensing means incorporated in removable or non-permanently secured container closures B65D47/00; for shops, stores, offices, bars, or the like A47F1/04; showcases or show cabinets with dispensing arrangements A47F3/02; magazines for screws or nuts in combination with spanners, wrenches or screwdrivers B25B23/06; for use in connection with the handling of sheets, webs, or filamentary material B65H
• CPC Class Codes: C08J 2373/00 Characterised by the use of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08J2359/00 - C08J2371/00; Derivatives of such polymers
• CPC Class Codes: C08J 9/0023 containing oxygen
• CPC Class Codes: C08J 9/0042 containing silicon
• CPC Class Codes: C08J 9/125 Water, e.g. hydrated salts
• CPC Class Codes: C11D 1/82 Compounds containing silicon
• CPC Class Codes: C11D 3/0094 : High foaming compositions
• CPC Class Codes: C11D 3/201 : linear
• CPC Class Codes: C11D 3/2013 : fatty or with at least 8 carbon atoms in the alkyl chain

Abstract

This invention relates to a method of producing and dispensing a foam using a “high lower alcohol content”(>40% v/v of a C_1-4 alcohol) liquid composition. The liquid compositions comprise an alcohol, C_1-4(>40% v/v), a silicone-based surfactant of at least 0.001% by weight to prepare a foamable composition, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and mosturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.

Claims

1. A method of producing and dispensing a foam using a foamable alcohol composition, the method comprising the steps of;

a) dispensing a foamable alcohol composition from a container having a dispenser pump configured to mix air with the foamable alcohol composition during dispensing to form a foam, the foamable alcohol composition comprising

i) a C_1-4 alcohol, or mixtures thereof, present in an amount greater than 40% v/v of the total composition;

ii) an effective physiologically acceptable silicone-based surfactant, comprising a lipophilic chain containing a silicone backbone for wetting and foaming present in an amount of at least 0.01% weight percent of the total composition; and

iii) water present in an amount to balance the total composition to 100% weight percent.

2. The method according to claim 1 wherein the dispenser is an unpressurized dispenser and whereby when a user activates the dispenser pump air is mixed with the composition under low pressure.

3. The method according to claim 1 wherein the effective silicone-based surfactant for wetting and foaming is physiologically compatible, and wherein the silicone-based surfactant is selected from the group consisting of silicone ethoxylates, silicone glycerol esters, silicone amine oxides, silicone acetylenic alcohol derivatives, silicone carboxylates, silicone sulphates, silicone phosphates, silicone Imidazole quats, silicone Amino Quats, silicone phosphate esters, silicone carbohydrate derivatives, silicone Isethionates, silicone sulfonates, silicone betaines, silicone Alkyl Quats, silicone Amino propionates, silicone esters, silicone polyamides, silicone fluorinated surfactants, and silicone hydrocarbon surfactants.

4. The method according to claim 1, wherein the effective physiologically acceptable silicone-based surfactant is selected from the group consisting of Bis-PEG-12 dimethicone, Bis-PEG-17 Dimethicone, Bis-PEG-20 Dimethicone, Bis-PEG-[10-20] dimethicones, 3-(3-Hydroxypropyl)-heptamethyltrisiloxane, ethoxylated, acetate, polyether-modified polysiloxanes, polysiloxane betaine and mixtures thereof, present in an amount from about 0.01% to about 10.0% weight percent of the total composition.

5. The method according to claim 1, wherein the alcohol C_1-4 is an aliphatic alcohol selected from the group consisting of methanol, ethanol, isopropanol, n-propanol, butanol and combinations thereof.

6. The method according to claim 1, wherein the alcohol is present in a range from about 40% to about 90% v/v.

7. The method according to claim 1, wherein the alcohol is selected from the group consisting of ethanol, n-propanol, a mixture of ethanol and n-propanol and a mixture of ethanol and isopropanol, present in an amount of at least 60% v/v, and wherein the composition is for use as an alcohol foam for personal hygiene.

8. The method according to claim 1, wherein the alcohol is isopropanol present in an amount of at least 70% v/v, and wherein the composition is for use as an alcohol foam for personal hygiene.

9. The method according to claim 1, further comprising at least one additional surfactant for adjusting properties of the foam produced from the composition.

10. The method according to claim 9 wherein the additional surfactant is selected from the group consisting of additional silicone-based surfactants, fluorinated surfactants, alkylglucosides, poly(ethoxylated) alcohol, poly(propoxylated)alcohol, a poly(ethoxylated ester, poly(propoxylated)ester, a derivative of a poly(ethoxylated) poly(propoxylated)alcohol, a derivative of a poly(ethoxylated)ester, poly(propoxylated)ester, an alkyl alcohol, an alkenyl alcohol, an ester of a polyhydric alcohol, an ether of a polyhydric alcohol, an ester of a polyalkoxylated derivative of a polyhydric alcohol, an ether of a polyalkoxylated derivative of a polyhydric alcohol, a sorbitan fatty acid ester, a polyalkoxylated derivative of a sorbitan fatty acid ester, a betaine, a sulfobetaine, an imidazoline derivative, an aminoacid derivative, a lecithin, a phosphatide, an amine oxide, a sulfoxide and mixtures thereof, present in an amount between about 0.10% to about 5% weight percent.

11. The method according to claim 10 wherein the betaine is cocamidopropyl betaine.

12. The method according to claim 10 wherein the alkylglucoside is cocoglucoside.

13. The method according to claim 10 wherein the polyethoxylated fatty alcohol is selected from the group consisting of polyethoxylated stearyl alcohol (21 moles ethylene oxide), polyethoxylated stearyl alcohol (2 moles ethylene oxide) and a combination thereof.

14. The method according to claim 10 wherein said fluorinated surfactant is selected from the group consisting of DEA C[8-18] perfluoroalkylethyl phosphate and ammonium C[6-16] perfluoroalkylethyl phosphate

15. The method according to claim 1 further comprising a foam stabilizing agent present in an amount up to about 10%.

16. The method according to claim 15 wherein the foam stabilizing agent is selected from the group consisting of lactic acid esters of monoglycerides, cationic emulsifiers, quaternary ammonium compounds, triquaternized stearic phospholipid complex, hydroxystearamide propyltriamine salts, lactic acid monoglycerides, food emulsifiers selected from the group consisting of glyceryl monostearate, propylene glycol monostearate, sodium stearoyl lactylate, cetyl betaine, glycolether, n-propanol, butyleneglycol, silicone wax, an encapsulated oil, Microcapsule Mineral Oil, glycerine, 2-butoxyethanol, butyleneglycol, Behentrimonium chloride, Cetrimonium Chloride and combinations thereof.

17. The method according to claim 1 further comprising any one of a moisturizer, emollient, lipid layer enhancers and combinations thereof selected from the group consisting of lanolin, vinyl alcohol, polyvinyl pyrrolidone and polyols selected from the group consisting of glycerol, propylene glycol, butyleneglycol, glyceryl oleate and sorbitol, cocoglucoside, a fatty alcohol selected from the group consisting of cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol and palmityl alcohol, cetyl alcohol, ceteareth 20, an alkylglucoside, mixtures of alkylglucoside and glyceryl Oleate, PEG-200 Hydrogenated Glyceryl Palmiate, Dihydroxypropyl PEG-5 Linoleammonium Chloride, PEG-7 Glyceryl Cocoate, and combinations thereof, present in an amount up to about 5%.

18. The method according to claim 1 further comprising an acid or a base to adjust a pH of the composition to a pre-selected pH present in an amount from about 0.05 to about 0.5% weight percent of the total composition.

19. The method according to claim 18 wherein when an acid is used to adjust the pH the acid is selected from the group consisting of hydrochloric acid, citric acid and phosphoric acid, and wherein when a base is used to adjust the pH the base is sodium sesquicarbonate.

20. The method according to claim 1 further comprising a preservative in an amount from about 0.01 to about 5% weight percent of the total composition.

21. The method according to claim 1 further comprising an antimicrobial agent selected from the group consisting of chlorhexidine salts, iodine, complexed forms of iodine, parachlorometaxylenol, triclosan, hexachlorophene, a phenol, a surfactant having a long chain hydrophobic group and a quaternary group, hydrogen peroxide, silver, a silver salt, silver oxide, behenyl alcohol, and mixtures thereof.

22. The method according to claim 1 further comprising constituents selected from the group consisting of organic gums and colloids, lower alkanolamides of higher fatty acids, short chain diols and/or triols, fragrance, coloring matter, ultraviolet absorbers, solvents, suspending agents, buffers, conditioning agents, antioxidants, bactericides and medicinally active ingredients, and combinations thereof.

23. The method according to claim 1 wherein the dispenser is a pressurized dispenser, and wherein the composition includes an aerosol propellant in an amount from about 3 to about 20 weight percent of the total composition, whereby when a user activates the dispenser pump air is mixed with the composition under high pressure.

24. The method according to claim 23 wherein the aerosol propellant is selected from the group consisting of propane, carbon dioxide, butane, dichloro difluoro methane, dichloro tetra fluoro ethane, octafluorocyclo butane;

1,1,1,2-tetrafluoroethane;

1,1,1,2,3,3,3 heptafluoropropane, and 1,1,1,3,3,3,-hexafluoropropane.

25. The composition according to claim 23 further comprising a corrosion inhibitor selected from the group consisting of sorbic acid, benzoic acid, potassium sorbate and sodium benzoate, in an amount from about 0.1 to about 5 weight percent of the total composition.

26. The method according to claim 1 further comprising a physiologically acceptable fluorosurfactant present in a range from about 0.01 to about 10% w/w, wherein said C_1-4 alcohol is present in an amount from about 40 to about 90 v/v of the total composition, and wherein the silicone-based surfactant for wetting and foaming present in an amount from about 0.1 to about 10%w/w weight percent of the total composition.

27. The method according to claim 26 wherein the fluorosurfactant is selected from the group consisting of fluorinated ethoxylates, glycerol esters, amine oxides, acetylenic alcohol derivatives, carboxylates, phosphates, carbohydrate derivatives, sulfonates, betaines, esters, polyamides, silicones, and hydrocarbon surfactants.

28. The method according to claim 26 wherein the fluorosurfactant is selected from the group consisting of an amphoteric polytetrafluoroethylene acetoxypropyl betaine (CF₃CF₂(CF₂CF₂)_nCH₂CH₂(OAc)CH₂N⁺(CH₃)₂CH₂COO⁻

) where n=2 to 4;

an ethoxylated nonionic fluorosurfactant of the following structure;

RfCH₂CH₂O(CH₂CH₂O)_xH where Rf=F(CF₂CF₂)y, x=0 to about 15, and y=1 to about 7; and

an anionic phosphate fluorosurfactant of the following structure;

(RfCH₂CH₂O)_xP(O)(ONH₄)_y where Rf=F(CF₂CF₂)z, x=1 or 2, y=2 or 1, x+y=3, and z=1 to about 7, and mixtures thereof.

29. The method according to claim 1 wherein said alcohol C_1-4, or mixtures thereof, is present in an amount between about 60% to about 80% v/v of the total composition and said effective physiologically acceptable silicone-based surfactant is present in an amount from about 0.01% to about 10.0% weight percent of the total composition, and wherein said composition further comprises a foam stabilizing agent present in an amount from about 0.01 to about 12.0% weight percent.

30. The method according to claim 29 in which said composition is formulated as a “

leave-on”

product not requiring washing after use of the foam.

43. The method according to claim 1 wherein the physiologically acceptable silicone-based surfactant consists essentially of a silicone surfactant.

31. A method of use of an alcohol foam composition for personal disinfecting, the method of use comprising providing an alcohol foam composition comprising;

a) air mixed under low pressure conditions; and

b) a liquid comprising

i) a C_1-4 alcohol, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition;

ii) an physiologically acceptable silicone-based surfactant having a lipophilic chain containing a silicone backbone, for wetting and foaming present in an amount of at least 0.01% weight percent of the total composition; and

iii) water present in an amount to balance the total composition to 100% weight percent.

32. The method according to claim 31 wherein the physiologically acceptable silicone-based surfactant for wetting and foaming is selected from the group consisting of silicone ethoxylates, silicone glycerol esters, silicone amine oxides, silicone acetylenic alcohol derivatives, silicone carboxylates, silicone sulphates, silicone phosphates, silicone Imidazole quats, silicone Amino Quats, silicone phosphate esters, silicone carbohydrate derivatives, silicone Isethionates, silicone sulfonates, silicone betaines, silicone Alkyl Quats, silicone Amino propionates, silicone esters, silicone polyamides, silicone fluorinated surfactants, and silicone hydrocarbon surfactants.

33. The method according to claim 31 wherein the physiologically acceptable silicone-based surfactant is selected from the group consisting of Bis-PEG-[10-20] dimethicones, 3-(3-Hydroxypropyl)-heptamethyltrisiloxane, ethoxylated, acetate, polyether-modified polysiloxanes, polysiloxane betaine and mixtures thereof from about 0.01% to about 10.0% weight percent of the total composition.

34. The method according to claim 31 wherein said liquid is stored in an unpressurized dispenser having a dispenser pump and the air is mixed with said liquid to form said foam under low pressure conditions.

35. The method according to claim 31 wherein said liquid is stored in a pressurized dispenser having a dispenser pump and air is mixed with said liquid to form said foam under high pressure conditions.

36. The method according to claim 31 wherein the physiologically acceptable silicone-based surfactant is present in a range from about 0.01% to about 10.0% weight percent of the total composition.

37. A method for producing, and applying to a person'"'"'s skin, a skin-disinfecting alcohol foam composition, comprising

a) combining an alcohol C_1-4, or mixtures thereof, present in an amount greater than about 60% v/v of the total composition with an effective physiologically acceptable silicone-based surfactant for foaming present in an amount of at least 0.001% by weight of the total composition, and water present in an amount to balance the total composition to 100% by weight to form an alcohol/silicone-based surfactant mixture and storing said composition in an unpressurized dispenser having a dispenser pump;

b) activating the dispenser pump to combine the alcohol/silicone-based surfactant mixture with air to form and dispense a skin-disinfecting alcohol foam; and

c) applying the skin-disinfecting alcohol foam to the person'"'"'s skin.

38. The method according to claim 37 wherein the physiologically acceptable silicone-based surfactant for wetting and foaming is selected from the group consisting of silicone ethoxylates, silicone glycerol esters, silicone amine oxides, silicone acetylenic alcohol derivatives, silicone carboxylates, silicone sulphates, silicone phosphates, silicone Imidazole quats, silicone Amino Quats, silicone phosphate esters, silicone carbohydrate derivatives, silicone Isethionates, silicone sulfonates, silicone betaines, silicone Alkyl Quats, silicone Amino propionates, silicone esters, silicone polyamides, silicone fluorinated surfactants, and silicone hydrocarbon surfactants.

39. The method according to claim 37 wherein the physiologically acceptable silicone-based surfactant is selected from the group consisting of Bis-PEG-[10-20] dimethicones, 3-(3-Hydroxypropyl)-heptamethyltrisiloxane, ethoxylated, acetate, polyether-modified polysiloxanes, polysiloxane betaine and mixtures thereof from about 0.01% to about 10.0% weight percent of the total composition.

40. The method according to claim 37 wherein said liquid is stored in an unpressurized dispenser having a dispenser pump and the air is mixed with said liquid to form said foam under low pressure conditions.

41. The method according to claim 37 wherein said liquid is stored in a pressurized dispenser having a dispenser pump and air is mixed with said liquid to form said foam under high pressure conditions.

42. The method according to claim 37 wherein the physiologically acceptable silicone-based surfactant is present in a range from about 0.01% to about 10.0% weight percent of the total composition.