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GASTRIC CANCER BIOMARKER DISCOVERY

  • US 20070259368A1
  • Filed: 05/03/2007
  • Published: 11/08/2007
  • Est. Priority Date: 05/03/2006
  • Status: Abandoned Application
First Claim
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1. A method for discovering a methylation marker gene for the conversion of a normal cell to gastric cancer cell comprising:

  • (i) comparing converted and unconverted cell gene expression content to identify a gene that is present in greater abundance in the unconverted cell;

    (ii) treating a converted cell with a demethylating agent and comparing its gene expression content with gene expression content of an untreated converted cell to identify a gene that is present in greater abundance in the cell treated with the demethylating agent; and

    (iii) selecting a gene that is common to the identified genes in steps (i) and (ii), wherein the common identified gene is the methylation marker gene.

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