Trajectory-based deep-brain stereotactic transcranial magnetic stimulation
First Claim
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1. A method for generating magnetic-field stimulation at a target position in neural tissue comprising the steps of:
- selecting a target position in neural tissue, providing an array of electromagnets, and orienting the electromagnets to deliver magnetic-field energy components to the target position; and
simultaneously energizing at least two of the electromagnets, whereby a stimulating vector component of the magnetic field received at the target position is greater than that received by locations more proximal to the electromagnets.
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Abstract
The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
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Citations
38 Claims
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1. A method for generating magnetic-field stimulation at a target position in neural tissue comprising the steps of:
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selecting a target position in neural tissue, providing an array of electromagnets, and orienting the electromagnets to deliver magnetic-field energy components to the target position; and
simultaneously energizing at least two of the electromagnets, whereby a stimulating vector component of the magnetic field received at the target position is greater than that received by locations more proximal to the electromagnets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for predicting displacement of an energy field in a region of a stimulation target, comprising the steps of:
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providing at least two data sets selecting from the data sets consisting of a first data set representing representing a calculated magnetic field strength distribution generated by a magnetic array;
a second data set representing a three dimensional location of a stimulation target in a brain, and a third data set representing the propensity of the stimulation target to convert magnetic field into electric field; and
registering at least two of the data sets on a three-dimensional coordinate system to create a registered data set. - View Dependent Claims (24)
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25. A neuromodulation system, comprising:
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an array of a plurality of electromagnets positionable in proximity to a brain having a predetermined target;
a power supply for energizing at least two of the electromagnets to cause the array to produce a composite magnetic field comprised of magnetic field components of each energized coil, the coils oriented relative to one another such that when energized, the strength of the composite magnetic field will be greatest at the target. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification