SYSTEM AND METHOD FOR MONITORING CARDIAC SIGNAL ACTIVITY IN PATIENTS WITH NERVOUS SYSTEM DISORDERS
First Claim
1. A medical device system comprising:
- a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal;
a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and
one or more processors adapted to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to;
receive the brain signal;
identify brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period;
receive the cardiac signal and store cardiac signal information in one or more data buffers;
identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period;
calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and
modify an output of the medical device system based upon the Inter-event HRV.
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Abstract
A medical device system and method for monitoring cardiac signal activity in patients with nervous system disorders. In some embodiments, a brain signal and a cardiac signal are received by a processor, brain events are identified in the brain signal, and the brain events are used to identify portions of the cardiac signal. In some embodiments, Event portions of the cardiac signal are identified corresponding to brain event time periods, and Inter-event portions are identified corresponding to time periods between brain events. An Inter-event heart-rate variability (HRV) calculation is performed using Inter-event portions of the cardiac signal, and an output of the medical device system is modified based upon the calculated Inter-event HRV according to certain embodiments of the invention. An Event HRV may also be calculated according to certain embodiments, and an output modified based on comparisons of the Event HRV to the Inter-event HRV, for example.
192 Citations
66 Claims
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1. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal;
a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and
one or more processors adapted to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to;
receive the brain signal;
identify brain events in the brain signal, each of the brain events having a start time and an end time defining a brain event time period;
receive the cardiac signal and store cardiac signal information in one or more data buffers;
identify one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period that is not a brain event time period;
calculate an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and
modify an output of the medical device system based upon the Inter-event HRV. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A method of treating a patient, the method comprising:
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receiving a brain signal from the patient;
identifying one or more brain events in the brain signal, each of the one or more brain events having a start time and an end time defining a brain event time period for each of the one or more brain events;
receiving a cardiac signal from the patient and storing cardiac signal information in one or more data buffers;
identifying one or more Inter-event portions of the cardiac signal, each of the one or more Inter-event portions corresponding in time to a period between two of the one or more brain event time periods;
calculating an Inter-event heart-rate variability (HRV) based on the cardiac signal information stored for the one or more Inter-event portions of the cardiac signal; and
modifying a therapy delivered to the patient based upon the calculated Inter-event HRV.
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48. A medical device system comprising:
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a brain monitoring element for sensing activity of a brain of a patient and outputting a brain signal;
a cardiac monitoring element for sensing activity of a heart of the patient and outputting a cardiac signal; and
one or more processors adapted to communicate with the brain monitoring element and the cardiac monitoring element, the one or more processors configured to;
receive the brain signal;
identify one or more brain events in the brain signal, each of the one or more brain events having a start time and an end time defining a brain event time period for each of the one or more brain events;
determine at least one reference point for a current brain event time period by evaluation of the brain signal, the current brain event time period following a preceding brain event time period by an inter-event interval;
receive the cardiac signal and store cardiac signal information in one or more data buffers;
identify a first portion and a second portion of the cardiac signal based on the at least one reference point of the current brain event time period;
calculate a first cardiac metric from the first portion of the cardiac signal and a second cardiac metric from the second portion of the cardiac signal;
compare the first cardiac metric to the second cardiac metric;
assign a weighting measure to the comparison of the first and second cardiac metrics based upon the inter-event interval; and
modify an output of the medical device system based on the weighting measure and on the comparison of the first cardiac metric to the second cardiac metric. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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Specification