Infusion Pumps and Methods for Use

• US 20070264130A1
• Filed: 05/04/2007
• Published: 11/15/2007
• Est. Priority Date: 01/27/2006
• Status: Abandoned Application

• Current Assignee: Tandem Diabetes Care Incorporated
• Original Assignee: Phluid, Inc.
• Inventors: Mallett, Scott
• Application Number:
  US11/744,819
• Publication Number:
  US 20070264130A1
• Time in Patent Office: Days
• US Class Current: 417/38
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure
• CPC Class Codes: F04B 9/127 rectilinear movement of the pumping member in the working direction being obtained by a single-acting elastic-fluid motor, e.g. actuated in the other direction by gravity or a spring
• CPC Class Codes: G01F 1/34 by measuring pressure or differential pressure
• CPC Class Codes: G01F 17/00 Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies measuring linear dimensions to determine volume G01B

Abstract

Infusion pump device and methods allow for determination of volumes and flow rates of fluids delivered. Determination is accomplished without direct measurement of either the fluid or flow rate, but by measuring pressure differentials of abutting chambers. The ideal gas law is used to calculate of the volumes and flow rates of the fluids dispended by the devices and via the methods disclosed herein.

Claims

1. A device comprising:

at least one first chamber;

at least one second chamber, each second chamber having a pressure sensor to measure pressure in each second chamber;

at least one third chamber having a dispensing port;

a device controlling the flow of gas from the first chamber to the second chamber;

a movable boundary between the second chamber and the third chamber; and

a processor.

2. The device of claim 1, wherein each first chamber having a pressure sensor to measure pressure in each first chamber.

3. The device of claim 1, further comprising:

a temperature sensor disposed in each first chamber and each second chamber.

4. The device of claim 1, wherein the volume of each first chamber is fixed.

5. The device of claim 1, wherein the volume of the second and third chambers is fixed.

6. The device of claim 5, wherein the volume of the third chamber is calculated by subtracting a total volume of the second chamber and the third chamber from the volume of the second chamber.

7. The device of claim 6, wherein the volume of the second chamber is determined by measuring pressure change in the second chamber and each first chamber before gas is moved from the first chamber into the second chamber and after gas is moved from the first chamber into the second chamber;

and

wherein the determination is accomplished using the ideal gas law.

8. The device of claim 1, wherein the device for transferring gas is a solenoid valve.

9. The device of claim 1, wherein the device for transferring gas comprises at least a restrictor.

10. The device of claim 1, wherein the movable boundary between the second and the third chamber is a piston.

11. The device of claim 1, wherein the movable boundary between the second chamber and the third chamber is a well of a flexible vessel holding a fluid to be delivered.

12. The device of claim 1, wherein the third chamber comprises one a flexible container holding a fluid.

13. The device of claim 1, wherein one or more first chambers comprise the chambers of a pump.

14. A method comprising:

providing at least one first chamber holding a gas;

providing at least one second chamber holding a gas;

providing at least one third chamber holding a fluid to be delivered;

determining a first pressure in each first chamber;

determining a first pressure in each second chamber;

transferring gas from at least one first chamber to at least one second chamber to determine the volume of a second chamber;

determining a second pressure in each first chamber;

determining a second pressure in each second chamber; and

calculating the dispensed volume of fluid from the third chamber based upon the determined first pressures and second pressures.

15. The method of claim 14, wherein the pressure of the gas in at least one first chamber is greater than the pressure of the gas in the second chamber that gas in the first chamber is transferred to.

16. The method of claim 15, wherein the pressure of the gas in the at least one first chamber is substantially greater than the pressure of the gas in the second chamber, wherein multiple aliquot of gas may be transferred from the first chamber into the second chamber resulting in the pressure of the first chamber remaining greater than the pressure of the second chamber.

17. The method of claim 14, further comprising initializing, wherein initializing further comprises:

preventing flow of the fluid to be delivered;

purging a portion of the gas from the second chamber;

determining a first initial pressure in each first chamber;

determining a first initial pressure in each second chamber; and

transferring gas from at least one first chamber to at least one second chamber.

18. The method of claim 17, wherein the initializing further comprises:

determining a second initial pressure in each first chamber after the gas has been transferred;

determining a second initial pressure in each second chamber after the gas has been transferred; and

calculating an initial volume of each second chamber.

19. The method of claim 17, wherein the initializing further comprises:

allowing the flow of the fluid to be delivered after each second initial pressure in each first chamber and in each second chamber has been measured.

20. A method comprising:

calculating the pressure difference in a first chamber and a second chamber after a gas has been transferred to calculate the volume of a third chamber by

a) determining the volume of the first chamber and the total volume of the second and third chambers.

b) determining the pressures of both the first chamber and second chamber prior to transfer of the gas from the first chamber to the second chamber;

c) transferring an aliquot of gas from the first chamber to the second chamber; and

d) determining the pressures of both the first chamber and the second chamber after the gas is transferred;

calculating the volume of the second chamber from the pressure data collected prior to the transfer of gas and the pressure data after the transfer of the gas using the ideal gas law;

calculating the volume of the third chamber by subtracting the volume of the second chamber from the total volume of the second and third chambers to determine the volume of fluid delivered.

21. The method of claim 20, further comprising including temperature measurements in the calculation of the volume of the second chamber by disposing temperature sensors in the first and second chambers and measuring temperature at the same time each pressure measurement is determined.