Method of enhancing penetration of water-soluble actives

• US 20070264210A1
• Filed: 05/15/2007
• Published: 11/15/2007
• Est. Priority Date: 05/15/2006
• Status: Abandoned Application

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Robinson, Larry Richard
• Application Number:
  US11/803,532
• Publication Number:
  US 20070264210A1
• Time in Patent Office: Days
• US Class Current: 424/59
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61K 8/895 containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A method of enhancing the delivery of water-soluble skin care actives into keratinous tissue, comprising the step of applying to the keratinous tissue a water-in-oil emulsion comprising an aqueous phase and a non-aqueous phase, wherein the aqueous phase comprises a water-soluble skin care active, and whereupon application of shear stress to the composition, the aqueous phase is visibly separated from the non-aqueous phase.

Claims

1. A method of enhancing the delivery of water-soluble skin care actives into keratinous tissue, comprising the step of applying to the keratinous tissue a composition comprising an water-in-oil emulsion comprising a aqueous phase and a non-aqueous phase, wherein the aqueous phase comprises a water-soluble skin care active, and whereupon application of shear stress to the composition, the aqueous phase is visibly separated from the non-aqueous phase, as evidenced by the visual presence of water droplets on the keratinous tissue.

2. The method of claim 1, wherein the composition comprises from about 1.2% to about 70% of the non-aqueous phase.

3. The method of claim 1, wherein the non-aqueous phase comprises an emulsifying crosslinked siloxane elastomer, a non-emulsifying crosslinked siloxane elastomer, and mixtures thereof.

4. The method of claim 3, wherein the non-aqueous phase comprises from about 0.1% to about 15% of the emulsifying crosslinked siloxane elastomer.

5. The method of claim 3, wherein the non-aqueous phase comprises from about 0.1% to about 15% of the non-emulsifying crosslinked siloxane elastomer.

6. The method of claim 3, wherein the composition comprises from about 1% to about 70%, by weight of the non-aqueous phase, of an elastomer solvent.

7. The method of claim 1, wherein the non-aqueous phase further comprises an oil-soluble skin care active.

8. The method of claim 7, wherein the oil-soluble skin care active is selected from the group consisting of vitamin E compounds, sunscreens, ultraviolet light absorbers, and combinations thereof.

9. The method of claim 1, wherein the water-soluble skin care active is selected from the group consisting of vitamin B compounds, vitamin C compounds, peptides and peptide derivatives, sugar amines, oil control agents, antioxidant precursors, radical scavengers, sunscreens, protease inhibitors, skin lightening agents, a sunless tanning agent, and mixtures thereof.

10. The method of claim 1, wherein the water-soluble skin care active is selected from the group consisting of niacinamide, an ascorbyl glucoside, N-acetyl glucosamine, dihydroxyacetone, a pentapeptide, hexamidine, sodium dehydroacetate, hydroquinone, undecylenoyl phenylalanine, cetyl pyridinium chloride, dihydroxyacetone, salts and derivatives thereof, and mixtures thereof.

11. The method of claim 1, wherein the aqueous phase comprises from about 0.001% to about 5% of at least one additional emulsifier.

12. The method of claim 11, wherein the additional emulsifier is a silicone emulsifier.

13. The method of claim 11, wherein the additional emulsifier is a non-silicone emulsifier.

14. A method of providing to a consumer an immediate benefit and of enhancing delivery of a skin care active into keratinous tissue, comprising the step of applying to keratinous tissue in need of a benefit a composition comprising from about 1.2% to about 70% of a non-aqueous phase and from about 30% to about 98.8% of a aqueous phase, wherein:

a) the non-aqueous phase comprises;

i. from about 0.1% to about 15%, by weight of the composition, of a non-emulsifying crosslinked siloxane elastomer;

ii. from about 0.1% to about 15%, by weight of the composition, of an emulsifying crosslinked siloxane elastomer;

iii. from about 1% to about 70%, by weight of the non-aqueous phase, of a solvent for the non-emulsifying and emulsifying crosslinked siloxane elastomers;

b) the aqueous phase comprises and at least one water-soluble skin care active selected from the group consisting of vitamin B compounds, vitamin C compounds, peptides and peptide derivatives, sugar amines, oil control agents, antioxidant precursors, radical scavengers, sunscreens, protease inhibitors, skin lightening agents, a sunless tanning agent, and mixtures thereof, and a dermatologically-acceptable carrier.

15. The method of claim 14, wherein the composition further comprises an oil-soluble skin care active selected from the group consisting of vitamin E compounds, sunscreens, ultraviolet light absorbers, and combinations thereof.

16. The method of claim 14, wherein the immediate benefit is the appearance of droplets of water.

17. The method of claim 14, wherein the skin care active provides a chronic benefit.

18. The method of claim 17, wherein the chronic benefit is selected from the group consisting of reducing signs of aging, reducing the appearance of wrinkles, reducing the appearance of deep lines, reducing the appearance of fine lines, reducing the appearance of large pores, reducing the thickness of keratinous tissue, increasing the convolution of the dermal-epidermal border, increasing elasticity, reducing the appearance of cellulite, reducing the appearance of discoloration, reducing the appearance of hyperpigmentation, reducing the appearance of under-eye circles, reducing the appearance of sallowness, and combinations thereof.

19. The method of claim 14, wherein the keratinous tissue is insult-affected mammalian skin.

20. The method of claim 19, wherein the insult-affected mammalian skin is selected from the group consisting of burned, sunburned, rash-affected, diaper rash-affected, shaving rash-affected, allergen-induced rash-affected, bleached, stained, hyperpigmented;

skin having nicks, skin having cuts, dry skin, rough skin, and combinations thereof.