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Immobilized Biologically Active Entities Having High Biological Activity Following Mechanical Manipulation

  • US 20070264308A1
  • Filed: 05/10/2007
  • Published: 11/15/2007
  • Est. Priority Date: 05/12/2006
  • Status: Active Grant
First Claim
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1. A medical device comprising:

  • a substrate material;

    a polymeric covering material attached to at least a portion of a surface of said substrate material, a plurality of biologically active entities having anti-thrombin III binding activity covalently attached to at least a portion of said polymeric covering material; and

    a biologically compatible composition covalently combined with said polymeric covering material, wherein said biologically active entities have an anti-thrombin III binding activity of at least 5 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material following compaction and expansion of said substrate material.

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