EXTRACELLULAR POLYSACCHARIDE SOLVATING SYSTEM FOR TREATMENT OF BACTERIAL EAR CONDITIONS
First Claim
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
- a) applying a solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % surfactant to a bacterial biofilm attached or adhered to at least a portion of the middle or inner ear, andb) detaching, removing or otherwise disrupting at least a part of the biofilm.
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Abstract
Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.
129 Citations
40 Claims
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1. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
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a) applying a solvating system comprising a metal ion sequestering agent and greater than 0.2 wt. % surfactant to a bacterial biofilm attached or adhered to at least a portion of the middle or inner ear, and b) detaching, removing or otherwise disrupting at least a part of the biofilm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17)
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14. A method for treating chronic otitis media and other bacterial ear conditions, which method comprises:
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a) applying a solvating system comprising a metal ion sequestering agent, a zwitterionic surfactant, and sufficient buffer so that the solvating system has a pH greater than 5 to a bacterial biofilm attached or adhered to at least a portion of the middle or inner ear, and b) detaching, removing or otherwise disrupting at least a part of the biofilm. - View Dependent Claims (18, 19)
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- 20. A solvating system for disrupting bacterial biofilms on tissue, the composition comprising a metal ion sequestering agent, greater than 0.2 wt. % surfactant, and an antimicrobial agent.
- 34. A solvating system for disrupting bacterial biofilms on tissue, the composition comprising a metal ion sequestering agent, a zwitterionic surfactant, and sufficient buffer so that the solvating system has a pH greater than 5.
Specification