BINARY COMPOSITIONS AND METHODS FOR STERILIZATION

• US 20070264355A1
• Filed: 12/14/2006
• Published: 11/15/2007
• Est. Priority Date: 12/14/2005
• Status: Abandoned Application

• Current Assignee: Binary LLC
• Original Assignee: Binary LLC
• Inventors: Becquerelle, Sophie, Allen, Robert, Woodhead, Suzan
• Application Number:
  US11/611,087
• Publication Number:
  US 20070264355A1
• Time in Patent Office: Days
• US Class Current: 424/615
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/00 Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application , e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A61L 2/0088 Liquid substances
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: C02F 1/722 Oxidation by peroxides
• CPC Class Codes: C02F 1/76 with halogens or compounds of halogens C02F1/4674 takes precedence
• CPC Class Codes: C02F 2303/20 Prevention of biofouling

Abstract

The present invention relates to binary methods and compositions comprising hypohalite (preferably hypochlorite) and peroxide (preferably hydrogen peroxide) directed to the killing of pathogenic microbes such as parasites, bacteria, fungi, yeast, and prions, the oxidation of toxins, and the preparation of potable water. The binary methods and compositions extend the microbicidal potency of conventional hypochlorite by providing additional singlet molecular oxygen generated in situ, and offer more control over reactive chlorination exposure than hypochlorite alone. This combination is a highly effective disinfecting and decontaminating agent, capable of disinfection, detoxification, or deactivation of biological contamination and many chemical toxins, facilitating the sterilizing of surfaces and solutions, and the production of potable water.

Claims

1. A method of decontaminating a surface or liquid target comprising contacting the target with a first composition comprising hypohalite for a first treatment time, and then contacting the target with a second composition comprising a sufficient amount of peroxide to react with substantially all of the hypohalite in the first composition for a second treatment time.

2. The method of claim 1 wherein the molar ratio of hypohalite in the first composition to peroxide in the second composition is 1:

1 or less.

3. The method of claim 2 wherein the molar ratio of hypohalite in the first composition to peroxide in the second composition is 1:

2 or less.

4. The method of claim 3 wherein the molar ratio of hypohalite in the first composition to peroxide in the second composition is 1:

4 or less.

5. The method of claim 1 wherein the first hypohalite composition comprises an aqueous solution of hypohalite.

6. The method of claim 5 wherein the hypohalite in the first composition is an alkali metal hypohalite.

7. The method of claim 6 wherein the alkali metal hypohalite is sodium hypochlorite.

8. The method of claim 7 wherein the concentration of sodium hypochlorite is from about 0.0001 mM to about 5 M.

9. The method of claim 7 wherein the concentration of sodium hypochlorite is from about 0.001 mM to about 1 M.

10. The method of claim 7 wherein the concentration of sodium hypochlorite is from about 0.01 mM to about 700 mM.

11. The method of claim 1 wherein the second peroxide composition comprises an aqueous solution of peroxide.

12. The method of claim 11 wherein the peroxide in the second composition is an alkali metal peroxide.

13. The method of claim 12 wherein the alkali metal peroxide is sodium peroxide.

14. The method of claim 11 wherein the peroxide in the second composition is hydrogen peroxide.

15. The method of claim 14 wherein the concentration of hydrogen peroxide is from about 0.001 mM to about 10 M.

16. The method of claim 14 wherein the concentration of hydrogen peroxide is from about 0.01 mM to about 1 M.

17. The method of claim 14 wherein the concentration of hydrogen peroxide is from about 0.1 mM to about 880 mM.

18. The method of claim 1 where the hypohalite in the first composition is sodium hypochlorite and the peroxide in the second composition is hydrogen peroxide.

19. The method of claim 18 wherein the concentration of sodium hypochlorite is from about 0.0001 mM to about 5 M and the concentration of hydrogen peroxide is from about 0.001 mM to about 10 M.

20. The method of claim 18 wherein the concentration of sodium hypochlorite is from about 0.001 mM to about 1 M and the concentration of hydrogen peroxide is from about 0.01 mM to about 1 M.

21. The method of claim 1 wherein the first treatment time is at least 1 minute.

22. The method of claim 1 wherein the first treatment time is at least 5 minutes.

23. The method of claim 1 wherein the first treatment time is at least 10 minutes.

24. The method of claim 1 wherein the second treatment time is at least 5 seconds.

25. The method of claim 1 wherein the second treatment time is at least 30 seconds.

26. The method of claim 1 wherein the second treatment time is at least 30 minutes.

27. The method of claim 1 where the surface is contaminated with a pathogenic agent.

28. The method of claim 27 wherein the pathogenic agent is selected from the group consisting of a bacterium, fungi, yeast, virus, and prions.

29. The method of claim 1 wherein the pathogenic agent is a microorganism in vegetative or spore form.

30. The method of claim 29 wherein the microorganism is in spore form.

31. The method of claim 30 wherein the microorganism in spore form is selected from the group consisting of Bacillus, Clostridia, and Sporosarcina.

32. The method of claim 31 wherein the microorganism in spore form is selected from the group consisting of Bacillus anthracis, Bacillus subtilis, Bacillus thuringiensis, and Clostridia botulinum.

33. The method of claim 1 wherein the target is an animal.

34. The method of claim 33 wherein the animal is human.

35. The method of claim 34 wherein the surface target is skin or hair.

36. The method of claim 1 wherein the surface target is on an inanimate object.

37. The method of claim 1 wherein the liquid target is contaminated water.

38. The method of claim 1 wherein the first composition, the second composition, or both the first and second compositions, further comprise one or more surfactants, detergents, or co-solvents.

39. The method of claim 38 wherein the surfactant or detergent is selected from group consisting of non-ionic, anionic, cationic zwitter-ionic surfactants, and detergents.

40. The method of claim 39 wherein the surfactant is selected from the group consisting of polyoxyethylene sorbitan esters, polyoxyethylene ethers, alkyl polyglucosides, alcohol or phenol ethoxylates, alkylamine ethoxylates, alkylarylether sulfates or sulfonates, alkyldiphenyloxide disulfonates, and alkylarylammonium halides.

41. The method of claim 40 wherein the surfactant is selected from the group consisting of polyoxyethylene sorbitan monooleate, polyethoxy cetylether, sodium octylphenoxypolyethoxyethyl sulfonate, sodium dodecyl sulfate, sodium deoxycholate, benzalkonium chloride, dodecyltrimethylammonium bromide, polyoxyl castor oil, polyoxyl hydrogenated castor oil, polyethylene-polypropylene glycol, octyl-beta-D-glucopyranoside, triethyleneglycol monododecylether, and dimethylpalmitylammonio-propane sulfonate.

42. The method of claim 38 wherein the co-solvent is selected from the group consisting of alcohols, glycerols, and glycols.

43. The method of claim 42 wherein the co-solvent is selected from the group consisting of isopropyl alcohol, butanol, glycerin, propylene glycol, and butanediols.

44. The method of claim 1 wherein the first composition, the second composition, or both the first and second compositions, further comprise one or more gelling agents, thixotropic agents, or viscosity enhancing agents.

45. The method of claim 44 wherein the gelling agent, thixotropic agent or viscosity enhancing agent is selected from the group consisting of amorphous colloidal silica gel, polyethylene glycols, methoxypolyethylene glycols, ethylcellulose, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and hydroxyethylcellulose, gelatin, and alginates.

46. The method of claim 1 wherein the first composition, the second composition, or both the first and second compositions, further comprise one or more detection agents.

47. The method of claim 46 wherein said first composition comprises a first detection agent and said second composition comprises a second detection agent wherein the first and second detection agents are not the same.

48. The method of claim 47 wherein the detection agent is selected from the group consisting of paint and dye.

49. The method of claim 48 wherein the detection agent is paint.

50. A kit for decontaminating a surface or a liquid target comprising a first container containing a first composition comprising hypohalite and a second container containing a second composition that comprises peroxide.

51. The kit of claim 50 wherein said first composition, said second composition, or both first and second compositions, further comprise one or more surfactants, detergents, co-solvents, gelling agents, thixotropic agents, viscosity enhancing agents, or detection agents.

52. The kit of claim 51 wherein said first composition comprises a first detection agent and said second composition comprises a second detection agent wherein the first and second detection agents are not the same.

53. The kit of claim 50 wherein the hypohalite is hypochlorite and the peroxide is hydrogen peroxide.