OPTICAL MEASUREMENT OF MITOCHONDRIAL FUNCTION IN BLOOD PERFUSED TISSUE
First Claim
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1. A system comprising:
- a data receiver configured to receive data corresponding to a spectrum of blood perfused tissue for a plurality of wavelengths;
a memory device configured to store the data and configured to store calibration spectra corresponding to the plurality of wavelengths; and
a processor coupled to the memory device and configured to execute instructions to generate a mitochondrial characteristic using the calibration spectra and the data.
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Abstract
This document describes, among other things, monitoring of intracellular oxygenation using an optical probe coupled to a multi-wavelength spectrometer. Multivariate analysis of the spectrum data yields quantifiable cellular characteristics.
28 Citations
28 Claims
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1. A system comprising:
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a data receiver configured to receive data corresponding to a spectrum of blood perfused tissue for a plurality of wavelengths;
a memory device configured to store the data and configured to store calibration spectra corresponding to the plurality of wavelengths; and
a processor coupled to the memory device and configured to execute instructions to generate a mitochondrial characteristic using the calibration spectra and the data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system comprising:
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an optical receiver configured to receive an optical signal from blood perfused tissue;
a spectrometer coupled to the optical receiver and configured to generate a reflectance spectrum for a plurality of wavelengths;
a memory device configured to store calibration spectra having data corresponding to the plurality of wavelengths; and
a processor coupled to the memory device and the spectrometer and configured to execute instructions to generate a mitochondrial characteristic using the calibration spectra and the absorption spectrum. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method comprising:
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receiving an optical signal from blood perfused tissue;
generating a reflectance spectrum for a plurality of wavelengths using the optical signal;
accessing a calibration spectra including data corresponding to the plurality of wavelengths; and
determining a mitochondrial characteristic using the calibration spectra and the reflectance spectrum. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A method comprising:
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receiving a reflectance spectrum from in vivo tissue; and
calculating a mitochondrial characteristic of the tissue using the reflectance spectrum and using a calibration set including data corresponding to in vitro solutions of at least one of myoglobin, hemoglobin, cytochrome c, and cytochrome oxidase. - View Dependent Claims (25, 26, 27, 28)
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Specification