Determination of a Measure of a Glycation End-Product or Disease State Using a Flexible Probe to Determine Tissue Fluorescence of Various Sites
First Claim
1. A method of determining a state of health of an individual where “
- state of health”
is any of (i) a disease state based on long-term changes (greater than one month duration) in tissue, (ii) a measure of chemical change based on long-term (greater than one month duration) glycemic control, (iii) a measure of glycation end-products in tissue, and (iv) a combination of the above, comprising;
a. Using a flexible probe, illuminating a portion of a tissue of the individual with excitation light;
b. Using the flexible probe, detecting light emitted from the tissue by fluorescence of a chemical within the tissue, where the tissue is not the tens of the eye;
c. Determining the state of health from the detected light and a model relating fluorescence and a state of health.
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Accused Products
Abstract
Embodiments of the present invention provide an apparatus with a flexible probe suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to a flexible optical probe. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.
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Citations
27 Claims
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1. A method of determining a state of health of an individual where “
- state of health”
is any of (i) a disease state based on long-term changes (greater than one month duration) in tissue, (ii) a measure of chemical change based on long-term (greater than one month duration) glycemic control, (iii) a measure of glycation end-products in tissue, and (iv) a combination of the above, comprising;
a. Using a flexible probe, illuminating a portion of a tissue of the individual with excitation light;
b. Using the flexible probe, detecting light emitted from the tissue by fluorescence of a chemical within the tissue, where the tissue is not the tens of the eye;
c. Determining the state of health from the detected light and a model relating fluorescence and a state of health. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16, 25, 26)
- state of health”
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13. A method as in claim 13, wherein the step of detecting light emitted by the tissue comprises homogenizing light emitted from the tissue before detecting the light.
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17. An apparatus for the determination of a state of health in an individual, where “
- state of health”
is any of (i) a disease state based on long-term changes (greater than one month duration) in tissue, (ii) a measure of chemical change based on long-term (greater than one month duration) glycemic control, (iii) a measure of glycation end-products in tissue, and (iv) a combination of the above, comprising;
a. An illumination subsystem adapted to supply excitation light;
b. A detection subsystem adapted to detect light, c. A flexible probe adapted to receive light from the illumination system and illuminate a portion of the tissue of the individual with excitation light, where the tissue is one or more of tissue on an extremity of the individual, tissue on the torso of the individual, or tissue on the head of the individual, and where the tissue is not the lens of the eye, and to collect light emitted from the tissue by fluorescence of a chemical within the tissue and transmit such light to the detection system, d. An analysis subsystem, comprising a model relating fluorescence property of the skin of an individual to a state of health. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 27)
- state of health”
Specification