Ultrasound Therapy System
First Claim
1. A system for treating an occlusion within a patient'"'"'s vasculature with ultrasonic energy, the system comprising:
- a catheter configured to be passed through the patient'"'"'s vasculature such that a portion of the catheter is positioned at an intravascular treatment site, wherein the catheter includes a fluid delivery lumen having a distal fluid delivery port;
an ultrasound radiating member positioned within the catheter;
an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member so as to cause ultrasonic energy to be delivered to the treatment site;
an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered through the distal fluid delivery port to the treatment site; and
a controller configured to control the ultrasound signal generator and the infusion pump such that (a) when the ultrasound signal generator is supplying the drive signal to the ultrasound radiating member the infusion pump is in an idle state, and (b) when the infusion pump is pumping a therapeutic compound into the fluid delivery lumen the ultrasound signal generator is in an idle state.
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Accused Products
Abstract
In one embodiment of the present invention, a system for treating an occlusion within a patient'"'"'s vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient'"'"'s vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.
482 Citations
46 Claims
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1. A system for treating an occlusion within a patient'"'"'s vasculature with ultrasonic energy, the system comprising:
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a catheter configured to be passed through the patient'"'"'s vasculature such that a portion of the catheter is positioned at an intravascular treatment site, wherein the catheter includes a fluid delivery lumen having a distal fluid delivery port;
an ultrasound radiating member positioned within the catheter;
an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member so as to cause ultrasonic energy to be delivered to the treatment site;
an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered through the distal fluid delivery port to the treatment site; and
a controller configured to control the ultrasound signal generator and the infusion pump such that (a) when the ultrasound signal generator is supplying the drive signal to the ultrasound radiating member the infusion pump is in an idle state, and (b) when the infusion pump is pumping a therapeutic compound into the fluid delivery lumen the ultrasound signal generator is in an idle state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system comprising:
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a catheter having a proximal region and a distal region, the catheter including (a) a fluid delivery lumen extending from an infusion port in the proximal region to a delivery port in the distal region, (b) an ultrasound radiating member positioned in the distal region, and (c) an elongate conductor extending from the ultrasound radiating member to the proximal region;
an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member via the elongate conductor;
a microbubble therapeutic compound reservoir coupled to the infusion port via an infusion pump, the infusion pump being configured to pump fluid from the microbubble therapeutic compound reservoir into the infusion port; and
a controller configured to control the ultrasound signal generator and the infusion pump such that (a) when the infusion pump is pumping fluid into the infusion port the ultrasound signal generator is not supplying a drive signal to the ultrasound radiating member, and (b) when the infusion pump is not pumping fluid into the infusion port the ultrasound signal generator is supplying a drive signal to the ultrasound radiating member. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of treating a vascular occlusion, the method comprising:
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providing an ultrasound catheter having a treatment zone, an ultrasound radiating member positioned within the treatment zone, and a fluid delivery lumen hydraulically coupled to an exit port within the treatment zone;
positioning the ultrasound catheter within a patient;
delivering, through the fluid delivery lumen and the exit port, a microbubble therapeutic compound to the internal portion of the vascular occlusion; and
delivering ultrasonic energy to the vascular occlusion, wherein the ultrasonic energy causes cavitation to occur within the microbubble therapeutic compound delivered to the vascular occlusion. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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31. A method of manufacturing an ultrasound catheter, the method comprising:
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providing an elongate catheter body having a distal region, a proximal region opposite the distal region, and an exterior surface;
positioning an ultrasound radiating member within the distal region of the elongate catheter body;
forming a fluid delivery lumen within the elongate catheter body, wherein the fluid delivery lumen extends between the proximal region and the distal region;
providing a fluid delivery port in the distal region of the elongate catheter body, the fluid delivery port being hydraulically connected to the fluid delivery lumen; and
forming a plurality of surface features on the exterior surface of the catheter body distal region using an ablative laser. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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39. An apparatus comprising:
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an elongate, hollow catheter body having a distal region, a proximal region opposite the distal region, and an exterior surface;
an ultrasound radiating member positioned with the distal region of the catheter body;
a fluid delivery lumen extending between the proximal region and the distal region of the catheter body; and
a plurality of holes formed in the exterior surface of the catheter body distal region. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46)
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Specification