Device and Method for Treating Weight Disorders
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Accused Products
Abstract
An apparatus and a method for treating a weight disorder in a subject are provided. The apparatus comprising an implantable device such as an inflatable balloon and electrodes capable of sensing a physiological change associated with food ingestion or hunger and a mechanism adapted for directly stimulating a region such as the duodenum which is responsive to a gastrointestinal satiety agent, such a mechanism can be a drug reservoir containing a drug such as CCK or analogs thereof which is contained within an inflatable balloon being implantable in a stomach of the subject. The apparatus and method provided here combine synergistic approaches to limiting meal size, i.e., chemo and mechano receptor activation of vagal satiety stimuli, electric stimulation of specific vagal pathways and limitations of gastric space.
185 Citations
100 Claims
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1-54. -54. (canceled)
- 55. An apparatus for treating a weight disorder in a subject comprising an implantable device capable of sensing a physiological change associated with food ingestion or hunger and a mechanism adapted for directly stimulating a region responsive to a gastrointestinal satiety agent.
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68. A method of treating a weight disorder comprising:
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a) implanting in a subject in need thereof a device capable of sensing a physiological change associated with food ingestion or hunger;
b) functionally associating with said device, a mechanism adapted for directly stimulating a region responsive to a gastrointestinal satiety agent; and
c) subsequent to sensing a physiological change associated with food ingestion or hunger by said device, activating said mechanism so as to directly stimulate said region. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
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- 81. An apparatus for treating a weight disorder in a subject comprising an implantable device capable of sensing a physiological change associated with food ingestion or hunger and a mechanism adapted for directly stimulating a region responsive to a gastrointestinal satiety agent, said mechanism comprising an inflatable balloon implantable in a stomach of a subject and a drug reservoir containing a drug capable of stimulating said region, said drug selected from the group consisting of CCK, a CCK analog, a CCK receptor agonist, a PYY, a PYY analog, GLP-1, a GLP-1 analog and oxyntomudulin.
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86. A method of treating a weight disorder comprising:
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a) implanting in a subject in need thereof a device capable of sensing a physiological change associated with food ingestion or hunger;
b) functionally associating with said device a mechanism adapted for directly stimulating a region responsive to a gastrointestinal satiety agent, said mechanism comprises an inflatable balloon being implantable in a stomach of the subject and a drug reservoir containing a drug capable of stimulation of said region, said drug is selected from the group consisting of CCK, a CCK analog, a CCK receptor agonist, a PYY, a PYY analog, GLP-1 and GLP-1 analog; and
c) subsequent to sensing a physiological change associated with food ingestion or hunger by said device, releasing said drug from said reservoir. - View Dependent Claims (87, 88, 89)
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90. An apparatus for treating a weight disorder in a subject comprising a distending object being implantable in a stomach of the subject and a drug reservoir containing a drug capable of stimulation a region responsive to a gastrointestinal satiety agent.
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91. A method of treatment, comprising:
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a) providing a pharmaceutical composition which comprises a peptide drug;
b) releasing said drug to an antral sphincter and/or a gastrointestinal wall so that said drug activates chemoreceptors on said antral sphincter and/or a gastrointestinal wall thereby causing a beneficial effect. - View Dependent Claims (92, 93)
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94. An apparatus for administering a drug to a luminal wall of a portion of the gastrointestinal tract, comprising:
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a) a drug dispersing tube and configured to release a drug to an antral sphincter and/or a gastrointestinal wall;
b) a drug releasing mechanism functionally associated with a drug reservoir and with said drug dispering tube, configured to release a dose of drug held in said drug reservoir out through said dispersing tube; and
c) a pharmaceutical composition including a peptide drug held in said drug reservoir. - View Dependent Claims (95, 96, 97, 98, 99, 100)
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Specification