Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea

• US 20070265606A1
• Filed: 05/15/2007
• Published: 11/15/2007
• Est. Priority Date: 02/14/2003
• Status: Abandoned Application

• Current Assignee: Reliant Technologies, Inc. (Bausch Health Cos., Inc.)
• Original Assignee: Reliant Technologies, Inc. (Bausch Health Cos., Inc.)
• Inventors: Frangineas, George, DeBenedictis, Leonard, Broome, Barry
• Application Number:
  US11/749,066
• Publication Number:
  US 20070265606A1
• Time in Patent Office: Days
• US Class Current: 606/15
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/201 with beam delivery through a hollow tube, e.g. forming an articulated arm through a flexible conduit A61B18/22; Hand-pieces therefor
• CPC Class Codes: A61B 2018/20351 Scanning mechanisms
• CPC Class Codes: A61B 2018/2055 with mechanical means
• CPC Class Codes: A61B 2018/20554 Arrangements for particular intensity distribution, e.g. tophat
• CPC Class Codes: A61B 2018/205547 Controller with specific architecture or programmatic algorithm for directing scan path, spot size or shape, or spot intensity, fluence or irradiance

Abstract

An apparatus and method are described that uses fractional light based treatment to shrink soft tissue in the mouth or throat to reduce obstruction of the airways for patients suffering from obstructive sleep apnea. A light delivery probe with scanning optics can be used to deliver treatment. Cooling systems can be added to reduce damage to epithelial layers of tissue. Light based treatment can be nonablative or ablative and is preferably performed with a laser.

Claims

1. An apparatus for achieving beneficial effects in a target tissue for the treatment of obstructive sleep apnea, the apparatus comprising:

an optical pattern generator including at least one of a scanner and an optical splitter, the optical pattern generator for directing an optical beam to generate an irradiation pattern at a target tissue, the target tissue including one or more of the uvula, soft palate and tongue, the irradiation pattern creating a plurality of microscopic treatment zones separated by untreated target tissue, wherein the pattern is defined at least in part by one or more of the scanner and the optical splitter; and

a probe for maintaining an optical channel within the human body for delivering the optical beam to the target tissue.

2. The apparatus of claim 1 wherein the pattern is defined at least in part by the scanner.

3. The apparatus of claim 1 wherein the irradiation pattern is predetermined.

4. The apparatus of claim 1 further comprising an ablative laser.

5. The apparatus of claim 4 wherein the ablative laser source has a wavelength that has an absorption in water of 100-1000 cm⁻

1.

6. The apparatus of claim 4 wherein the ablative laser comprises a CO₂ laser source.

7. The apparatus of claim 1 further comprising a nonablative laser.

8. The apparatus of claim 7 wherein the nonablative laser comprises an erbium-doped fiber laser source.

9. The apparatus of claim 1 wherein the microscopic treatment zones have a width of between approximately 80 and 1000 μ

m.

10. The apparatus of claim 1 wherein the microscopic treatment zones have a width of between approximately 200 and 500 μ

m.

11. The apparatus of claim 1 wherein a volume of untreated target tissue is greater than a volume of microscopic treatment zones.

12. The apparatus of claim 1 wherein the irradiation pattern comprises an annular pattern.

13. The apparatus of claim 1 wherein the irradiation pattern comprises a plurality of deblurred spots.

14. The apparatus of claim 1 wherein the irradiation pattern comprises an irregular pattern of illuminated spots.

15. The apparatus of claim 1 wherein the probe comprises an optical window in direct contact with the target tissue, the optical beam passing through the optical window.

16. The apparatus of claim 15 wherein the optical window is thermally conductive.

17. The apparatus of claim 1 wherein the probe comprises an optical window that is spaced away from the target tissue, the optical beam passing through the optical window.

18. The apparatus of claim 1 further comprising:

a controller coupled to monitor motion of the probe and for controlling the optical beam and/or the optical pattern generator based on the motion of the probe.

19. The apparatus of claim 1 further comprising:

a controller for controlling at least one of the following parameters for the optical beam;

treatment zone pattern, exposure period, and energy density distribution.

20. The apparatus of claim 1 further comprising:

a sensor for monitoring treatment of the target tissue; and

a controller coupled to the sensor for controlling irradiation of the target tissue based on the monitored treatment.

21. The apparatus of claim 1 wherein the optical pattern generator comprises:

a single rotatable component having a plane of rotation and a rotation axis, the rotatable component comprising a plurality of deflection sectors arranged in a pattern around the rotation axis, wherein each sector deflects the optical beam as the sector rotates through the optical beam to generate the predetermined irradiation pattern at the target tissue.

22. The apparatus of claim 21 wherein the deflection sectors are arranged approximately in a circle centered on the rotation axis, and the sectors are substantially self-compensating with respect to a rotation of the rotatable component and are substantially spatially invariant with respect to a wobble of the rotatable component.

23. The apparatus of claim 21 wherein each sector is adapted to deflect the incident optical beam by a substantially constant angular deflection that is primarily in the plane of rotation.

24. The apparatus of claim 21 wherein, for a majority of the deflection sectors on the rotatable component, the sector comprises a pair of opposing reflective surfaces that have a substantial component in the plane of rotation for deflecting the incident collimated optical beam toward different points in the irradiation pattern.

25. The apparatus of claim 21 wherein the rotatable component comprises a plurality of discrete structures arranged approximately around the rotation axis adjacent to the sectors, each discrete structure having at least two reflective faces, and reflective faces from adjacent structures form opposing reflective surfaces for the sectors.

26. The apparatus of claim 1 wherein the optical pattern generator comprises:

two counter-rotating disks for deflecting an incident optical beam to generate the predetermined irradiation pattern at the target tissue.

27. The apparatus of claim 26 wherein the irradiation pattern comprises a plurality of spots, the counter-rotating disks have pairs of corresponding facets and each pair of corresponding facets generates one of the spots and the spot is substantially stationary as the pair of facets rotates through the incident optical beam.

28. The apparatus of claim 26 wherein the two counter-rotating disks comprise pairs of corresponding facets and one facet of a pair of corresponding facets behaves as a positive lens and the other facet behaves as a negative lens.

29. The apparatus of claim 28 wherein the centers of rotation of the two counter-rotating disks is separated by a distance L and the optical centers of the positive lens and the negative lens are also separated by the distance L.

30. The apparatus of claim 28 wherein the centers of rotation of the two counter-rotating disks is separated by a distance L and the optical centers of the positive lens and the negative lens are separated by a distance approximately equal to L but not exactly equal to L, in order to correct for residual cross-scan angular displacement of the deflected optical beam.

31. The apparatus of claim 28 wherein at least one of the facets includes an aspheric surface for correcting for residual cross-scan angular displacement of the deflected optical beam.

32. The apparatus of claim 28 wherein the positive lens and the negative lens have slightly different focal lengths in order to correct for residual cross-scan angular displacement of the deflected optical beam.

33. A method for treating obstructive sleep apnea, the method comprising:

generating an optical beam;

directing the optical beam to generate an irradiation pattern at a target tissue that contributes to a condition of obstructive sleep apnea, the irradiation pattern creating a plurality of microscopic treatment zones separated by untreated target tissue;

maintaining an optical channel within the human body; and

delivering the optical beam to the target tissue via the optical channel.

34. The method of claim 33, wherein the median diameter of the microscopic treatment zones is in the range of 80-1000 μ

m.