Computational methods and systems for augmenting cell-mediated immune response

• US 20070265788A1
• Filed: 05/25/2007
• Published: 11/15/2007
• Est. Priority Date: 08/24/2004
• Status: Abandoned Application

• Current Assignee: Deep Science LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward, Wilson, Richa, Sweeney, Elizabeth, Bangera, Mahalaxmi, Myhrvold, Nathan, Wood, Lowell, Ishikawa, Muriel
• Application Number:
  US11/807,337
• Publication Number:
  US 20070265788A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

The present application relates, in general, to a system and/or method related to detection and/or treatment.

Claims

1. A system comprising:

at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to;

one or more instructions for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents; and

one or more instructions for selecting one or more immune response components in response to the projecting.

2. The system of claim 1, wherein the one or more instructions for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

one or more instructions for identifying an association of at least a computable portion of at least one of;

a pathogen, a virus, a bacterium, a toxin, a prion, or a cell.

3. The system of claim 1, wherein the one or more instructions for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

one or more instructions for identifying an association of at least a computable portion of one or more agents with an autoimmune response.

4. The system of claim 1, wherein the one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents associated with at least one disease state.

5. The system of claim 1, wherein the one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

one or more instructions for projecting a pattern of one or more changes associated with agent pathogenicity.

6. The system of claim 1, wherein the one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

one or more instructions for projecting a pattern of one or more changes associated with agent transmission.

7. The system of claim 1, wherein the one or more instructions for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

one or more instructions for projecting at least one pattern associated with at least one protein sequence change.

8. The system of claim 1, wherein the one or more instructions for selecting one or more immune response components in response to the projecting further comprises:

one or more instructions for selecting at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

9. The system of claim 1, wherein the one or more instructions for selecting one or more immune response components in response to the projecting further comprises:

one or more instructions for selecting one or more modulators of at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

10. The system of claim 1, wherein the one or more instructions selecting one or more immune response components in response to the projecting further comprises:

one or more instructions for selecting at least a part of one or more of an;

cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokine, cytokine, or autocoid.

11. The system of claim 1, wherein the one or more instructions for selecting one or more immune response components in response to the projecting further comprises:

one or more instructions for selecting one or more modulators of at least a part of one or more of an;

T cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokines, cytokine, or autocoid.

12. The system of claim 1, further comprising:

one or more instructions including referencing at least one database.

13. A system, comprising:

circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents; and

circuitry for selecting one or more immune response components in response to the projecting.

14. The system of claim 13, wherein the circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

circuitry for identifying an association of at least a computable portion of at least one of;

a pathogen, a virus, a bacterium, a toxin, a prion, or a cell.

15. The system of claim 13, wherein the circuitry for identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

circuitry for identifying an association of at least a computable portion of one or more agents with an autoimmune response.

16. The system of claim 13, wherein the circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents associated with at least one disease state.

17. The system of claim 13, wherein the circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

circuitry for projecting a pattern of one or more changes associated with agent pathogenicity.

18. The system of claim 13, wherein the circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

circuitry for projecting a pattern of one or more changes associated with agent transmission.

19. The system of claim 13, wherein the circuitry for projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

circuitry for projecting at least one pattern associated with at least one protein sequence change.

20. The system of claim 13, wherein the circuitry for selecting one or more immune response components in response to the projecting further comprises:

circuitry for selecting at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

21. The system of claim 13, wherein the circuitry for selecting one or more immune response components in response to the projecting further comprises:

circuitry for selecting one or more modulators of at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

22. The system of claim 13, wherein the circuitry for selecting one or more immune response components in response to the projecting further comprises:

circuitry for selecting at least a part of one or more of an;

T cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokine, cytokine, or autocoid.

23. The system of claim 13, wherein the circuitry for selecting one or more immune response components in response to the projecting further comprises:

circuitry for selecting one or more modulators of at least a part of one or more of an;

T cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokines, cytokine, or autocoid.

24. The system of claim 13, further comprising:

circuitry for referencing at least one database.

25. A method, comprising:

identifying an association of at least a computable portion of one or more agents with at least a part of an immune response;

projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents; and

selecting one or more immune response components in response to the projecting.

26. The method of claim 25, wherein identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

identifying an association of at least a computable portion of at least one of;

a pathogen, a virus, a bacterium, a toxin, a prion, or a cell.

27. The method of claim 25, wherein identifying an association of at least a computable portion of one or more agents with at least a part of an immune response further comprises:

identifying an association of at least a computable portion of one or more agents with an autoimmune response.

28. The method of claim 25, wherein projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents associated with at least one disease state.

29. The method of claim 25, wherein projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

projecting a pattern of one or more changes associated with agent pathogenicity.

30. The method of claim 25, wherein projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

projecting a pattern of one or more changes associated with agent transmission.

31. The method of claim 25, wherein projecting a pattern of one or more changes relating to the at least a computable portion of one or more agents further comprises:

projecting at least one pattern associated with at least one protein sequence change.

32. The method of claim 25, wherein selecting one or more immune response components in response to the projecting further comprises:

selecting at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

33. The method of claim 25, wherein selecting one or more immune response components in response to the projecting further comprises:

selecting one or more modulators of at least a part of one or more of an;

immune cell, lymphoid cell, myeloid cell, T cell, B cell, or Natural Killer T Cell.

34. The method of claim 25, wherein selecting one or more immune response components in response to the projecting further comprises:

selecting at least a part of one or more of an;

T cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokine, cytokine, or autocoid.

35. The method of claim 25, wherein selecting one or more immune response components in response to the projecting further comprises:

selecting one or more modulators of at least a part of one or more of an;

T cell receptor, B cell receptor, antibody, MHC molecule, CD1 molecule, adhesion molecule, cell surface molecule, cell surface receptor, chemokines, cytokine, or autocoid.

36. The method of claim 25, further comprising:

referencing at least one database.