Computational methods and systems for heightening cell-mediated immune response

• US 20070265818A1
• Filed: 05/25/2007
• Published: 11/15/2007
• Est. Priority Date: 08/24/2004
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Jung, Edward, Wilson, Richa, Sweeney, Elizabeth, Bangera, Mahalaxmi, Myhrvold, Nathan, Wood, Lowell, Ishikawa, Muriel
• Application Number:
  US11/807,335
• Publication Number:
  US 20070265818A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: G16B 5/00 ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Abstract

The present application relates, in general, to a system and/or method related to detection and/or treatment.

Claims

1. A system comprising:

at least one computer program for use with a computer system and wherein the computer program includes a plurality of instructions including but not limited to

one or more instructions for providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host; and

one or more instructions for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host.

2. The system of claim 1, wherein the one or more instructions for providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host further comprises:

one or more instructions for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host.

3. The system of claim 2, wherein the one or more instructions for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host further comprises:

one or more instructions for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least one response to at least one treatment.

4. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set including one or more computable attributes associated with display by the one or more agents.

5. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set including one or more computable attributes present in a copy number of at least two.

6. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set including one or more computable attributes present in at least two of the one or more agents.

7. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set including one or more computable attributes with at least one sequence match to at least a part of the at least one host.

8. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set including at least one computable epitope arising from a substantially nonlinear form.

9. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set of the one or more computable attributes of one or more agents associated with being amenable to at least one treatment.

10. The system of claim 9, wherein the at least one treatment includes:

at least one treatment of at least a part of at least one immune response component.

11. The system of claim 9, wherein the at least one treatment includes:

at least one treatment of at least one modulator of at least a part of at least one immune response component.

12. The system of claim 1, wherein the one or more instructions for forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

one or more instructions for forming a set in reference to at least one meta-signature.

13. The system of claim 1, further comprising:

one or more instructions for producing as output one or more sequences corresponding to the one or more computable attributes of one or more agents.

14. The system of claim 1, further comprising:

one or more instructions for projecting one or more alternate courses of the at least a part of the immune response of the at least one host associated with the one or more computable attributes of one or more agents.

15. The system of claim 1, further comprising:

one or more instructions for associating the at least a part of an immune response in at least one host with at least one disease state.

16. The system of claim 1, further comprising:

one or more instructions for associating the one or more computable attributes of one or more agents with at least one disease state.

17. A system comprising:

circuitry for providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host; and

circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host.

18. The system of claim 17, wherein the circuitry for providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host further comprises:

circuitry for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host.

19. The system of claim 18, wherein the circuitry for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host further comprises:

circuitry for projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least one response to at least one treatment.

20. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host further comprises:

circuitry for forming a set including one or more computable attributes associated with display by the one or more agents.

21. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host further comprises:

circuitry for forming a set including one or more computable attributes present in a copy number of at least two.

22. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host further comprises:

circuitry for forming a set including one or more computable attributes present in at least two of the one or more agents.

23. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host further comprises:

circuitry for forming a set including one or more computable attributes with at least one sequence match to at least a part of the at least one host.

24. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host further comprises:

circuitry for forming a set including at least one computable epitope arising from a substantially nonlinear form.

25. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating the at least a part of the immune response in one or more of the at least one host further comprises:

circuitry for forming a set of the one or more computable attributes of one or more agents associated with being amenable to at least one treatment.

26. The system of claim 25, wherein the at least one treatment includes:

at least one treatment of at least a part of at least one immune response component.

27. The system of claim 25, wherein the at least one treatment includes:

at least one treatment of at least one modulator of at least a part of at least one immune response component.

28. The system of claim 17, wherein the circuitry for forming a set of the one or more computable attributes operable for modulating the at least a part of the immune response in one or more of the at least one host further comprises:

circuitry for forming a set in reference to at least one meta-signature.

29. The system of claim 17, further comprising:

circuitry for producing as output one or more sequences corresponding to the one or more computable attributes of one or more agents.

30. The system of claim 17, further comprising:

circuitry for projecting one or more alternate courses of the at least a part of the immune response of the at least one host associated with the one or more computable attributes of one or more agents.

31. The system of claim 17, further comprising:

circuitry for associating the at least a part of an immune response in at least one host with at least one disease state.

32. The system of claim 17, further comprising:

circuitry for associating the one or more computable attributes of one or more agents with at least one disease state.

33. A method, comprising:

providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host; and

forming a set of the one or more computable attributes operable for modulating at least a part of an immune response in one or more of the at least one host.

34. The method of claim 33, wherein the providing one or more computable attributes of one or more agents associated with at least a part of an immune response in at least one host further comprises:

projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host.

35. The method of claim 34, wherein the projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least a part of the immune response of one or more of the at least one host further comprises:

projecting at least one pattern of change in the one or more computable attributes of one or more agents associated with at least one response to at least one treatment.

36. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

forming a set including one or more computable attributes associated with display by the one or more agents.

37. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

forming a set including one or more computable attributes present in a copy number of at least two.

38. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

forming a set including one or more computable attributes present in at least two of the one or more agents.

39. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

forming a set including one or more computable attributes with at least one sequence match to at least a part of the at least one host.

40. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of an immune response in one or more of the at least one host further comprises:

forming a set including at least one computable epitope arising from a substantially nonlinear form.

41. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of the immune response in one or more of the at least one host further comprises:

forming a set of the one or more computable attributes of one or more agents associated with being amenable to at least one treatment.

42. The method of claim 41, wherein the at least one treatment includes:

at least one treatment of at least a part of at least one immune response component.

43. The method of claim 41, wherein the at least one treatment includes:

at least one treatment of at least one modulator of at least a part of at least one immune response component.

44. The method of claim 33, wherein the forming a set of the one or more computable attributes operable for modulating the at least a part of the immune response in one or more of the at least one host further comprises:

forming a set in reference to at least one meta-signature.

45. The method of claim 33, further comprising:

producing as output one or more sequences corresponding to the one or more computable attributes of one or more agents.

46. The method of claim 33, further comprising:

projecting one or more alternate courses of the at least a part of the immune response of the at least one host associated with the one or more computable attributes of one or more agents.

47. The method of claim 33, further comprising:

associating the at least a part of an immune response in at least one host with at least one disease state.

48. The method of claim 33, further comprising:

associating the one or more computable attributes of one or more agents with at least one disease state.