DEVICES, METHODS, AND SYSTEMS FOR DELIVERING THERAPEUTIC AGENTS FOR THE TREATMENT OF SINUSITIS, RHINITIS, AND OTHER DISORDERS
First Claim
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1. A method for treating a body lumen selected from the group consisting of sinus, nasal, pharynx, and Eustachian cavities, said method comprising delivering at least one agent into sub-epithelial or peri-luminal tissue surrounding the body lumen.
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Abstract
Methods and kits for delivering pharmaceutical agents to the sinuses, sinus ostia, Eustachian tube, and pharynx are presented. A needle tip is translated through the mucosal tissue layer to a sub-epithelial or peri-luminal orientation and pharmaceutical agents are delivered into the sub-epithelial or peri-luminal tissue. Drugs distribute from the site of infusion to treat conditions including sinusitis and allergic rhinitis, among others.
249 Citations
27 Claims
- 1. A method for treating a body lumen selected from the group consisting of sinus, nasal, pharynx, and Eustachian cavities, said method comprising delivering at least one agent into sub-epithelial or peri-luminal tissue surrounding the body lumen.
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25. A device for delivering agents across the mucosa of a sinus, sinus ostium, Eustachian tube, or pharynx, said device comprising:
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a catheter adapted for insertion into the paranasal sinuses, sinus ostia, Eustachian tube, or pharynx;
a hollow microneedle deployable from the catheter;
wherein the microneedle is adapted to be advanced from the catheter into or through the mucosa and beyond the epithelium for the delivery of therapeutic or diagnostic agents.
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26. A method for delivering an agent into the sub-epithelial or peri-luminal tissue surrounding a body lumen selected from the group consisting of a sinus, nasal, pharynx, and Eustacian cavity, said method comprising:
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positioning a catheter through a patient'"'"'s nose or sinusotomy into one of the body lumens;
advancing a needle from the catheter through a mucosal wall into sub-epithelial or peri-luminal tissue surrounding the body lumen; and
delivering the agent into the sub-epithelial or peri-luminal tissue through the needle. - View Dependent Claims (27)
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Specification