Porous silicon materials and devices

• US 20070269411A1
• Filed: 03/07/2007
• Published: 11/22/2007
• Est. Priority Date: 03/10/2006
• Status: Abandoned Application

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Sun, Wei, Fauchet, Philippe, Puzas, J.
• Application Number:
  US11/715,819
• Publication Number:
  US 20070269411A1
• Time in Patent Office: Days
• US Class Current: 424/93.200
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C12N 15/86 Viral vectors
• CPC Class Codes: C12N 2710/10351 Methods of production or purification of viral material

Abstract

Provided are materials and devices comprising physiologically acceptable silicon. The materials and devices can comprise a vector, including a viral vector.

Claims

1. A material, comprising physiologically acceptable silicon having a plurality of pores, one or more pore having a diameter of between about 50 nanometers (nm) and about 10.0 microns (μ

m).

2. The material of claim 1, wherein at least one pore has a diameter of between about 500 nm and about 5 μ

m.

3. The material of claim 1, wherein at least one pore has a diameter of between about 1.0 μ

m and about 2.0 μ

m.

4. The material of claim 1, further comprising a human or animal cell.

5. The material of claim 4, wherein the cell is located in a pore.

6. The material of claim 4, wherein the cell is a stem cell.

7. The material of claim 4, wherein the material further comprises extracellular matrix.

8. The material of claim 7, wherein the extracellular matrix has a calcium phosphorous ratio of greater than 1.17.

9. The material of claim 1, further comprising a pharmacologic agent.

10. The material of claim 9, wherein the pharmacologic agent produces an anti-cancer or osteoinductive effect in a subject.

11. The material of claim 1, further comprising a vector, wherein the vector comprises at least one nucleic acid sequence encoding a pharmacologic agent.

12. The material of claim 11, wherein the pharmacological agent is a therapeutic protein or a therapeutic portion thereof.

13. The material of claim 11, wherein the pharmacological agent produces an osteoinductive effect in a subject.

14. The material of claim 11, wherein the vector is a viral vector.

15. The material of claim 12, wherein the therapeutic protein or therapeutic portion thereof produces an anti-cancer effect in a subject having a cancer.

16. The material of claim 1, further comprising a plurality of physiologically acceptable silicon particles each particle having a plurality of pores, one or more pore having a diameter of between about 50 nm and about 10.0 μ

m.

17. The material of claim 16, wherein at least one pore has a diameter of between about 1.0 μ

m and about 2.0 μ

m.

18. The material of claim 16, further comprising a bonding agent.

19. The material of claim 18, wherein the material can be molded into a medical device.

20. The material of claim 19, wherein the medical device is selected from the group consisting of:

a pin, a nail, a screw, a plate, a staple, a tack, an anchor, a fiber, a mesh, a scaffold, a powder, and a fixation block.

37. The device of claim 15, further comprising a plurality of physiologically acceptable silicon particles, each particle having a plurality of pores, one or more pore having a diameter of between about 50 nm and about 10.0 μ

m, wherein the plurality of the particles are positioned in relation to each other to form at least a portion of the medical device.

38. The device of claim 37, wherein at least one pore has a diameter of between about 1.0 μ

m and about 2.0 μ

m.

21. A device, comprising physiologically acceptable silicon having a plurality of pores, one or more pore having a diameter of between about 50 nm and about 10.0 μ

m, wherein the device is implantable within a subject.

22. The device of claim 21, wherein at least one pore has a diameter of between about 500 nm and about 5.0 μ

m.

23. The device of claim 21, wherein at least one pore has a diameter of between about 1.0 μ

m and about 2.0 μ

m.

24. The device of claim 21, wherein the device is selected from the group consisting of:

a pin, a nail, a screw, a plate, a staple, a tack, an anchor, a fiber, a mesh, a scaffold, a powder, and a fixation block.

25. The device of claim 21, further comprising a human or animal cell.

26. The device of claim 25, wherein the cell is attached to at least one pore.

27. The device of claim 25, wherein the cell is a stem cell.

28. The device of claim 25, wherein the material further comprises extracellular matrix.

29. The device of claim 28, wherein the extracellular matrix has a calcium phosphorous ratio of greater than 1.17.

30. The device of claim 21, further comprising a pharmacologic agent.

31. The material of claim 30, wherein the pharmacologic agent produces an anti-cancer or osteoinductive effect in a subject.

32. The device of claim 21, further comprising a vector, wherein the vector comprises at least one nucleic acid sequence encoding a pharmacologic agent.

33. The device of claim 32, wherein the pharmacological agent is a therapeutic protein or a therapeutic portion thereof.

34. The device of claim 32, wherein the pharmacological agent produces an osteoinductive effect in a subject.

35. The device of claim 32, wherein the vector is a viral vector.

36. The device of claim 33, wherein the therapeutic protein or therapeutic portion thereof produces an anti-cancer effect in a subject having a cancer.

39. A device, comprising a plurality of physiologically acceptable silicon particles, wherein the plurality of the particles are positioned in relation to each other to form at least a portion of the device, the device having one or more pore with a diameter of between about 50 nm and about 10.0 μ

m.

40. The device of claim 39, wherein at least one pore has a diameter of between about 1.0 μ

m and about 2.0 μ

m.

41. A material, comprising physiologically acceptable silicon and a vector, wherein the vector comprises at least one nucleic acid sequence encoding a pharmacological agent.

42. The material of claim 41, wherein the pharmacological agent is a therapeutic protein or a therapeutic portion thereof.

43. The material of claim 41, wherein the pharmacological agent produces an osteoinductive effect in a subject.

44. The material of claim 41, wherein the vector is a viral vector.

45. The material of claim 44, wherein the viral vector is an adenoviral vector.

46. The material of claim 42, wherein the therapeutic protein or therapeutic portion thereof produces an anti-cancer effect in a subject having a cancer.

47. The material of claim 41, wherein the material comprises Ad-BMP-2.

48. The material of claim 41, wherein the vector is attached to a portion of the silicon.

49. A device, comprising the material of claim 41, wherein the device is implantable within a subject.

50. A material, comprising a plurality of physiologically acceptable silicon particles each particle comprising physiologically acceptable silicon and a vector, wherein the vector comprises at least one nucleic acid sequence encoding a pharmacological agent.