Soluble recombinant botulinum toxin proteins
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Abstract
The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A, type B and type E toxin proteins are provided. Methods which allow for the isolation of recombinant proteins free of significant endotoxin contamination are provided. The soluble, endotoxin-free recombinant proteins are used as immunogens for the production of vaccines and antitoxins. These vaccines and antitoxins are useful in the treatment of humans and other animals at risk of intoxication with clostridial toxin.
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Citations
62 Claims
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1-49. -49. (canceled)
- 50. A composition comprising an active soluble recombinant botulinum neurotoxin, which comprises a non-toxin protein sequence and a botulinum toxin type B protein sequence having proteolytic activity.
- 54. A composition comprising an active soluble recombinant botulinum neurotoxin, which comprises a non-toxin protein sequence and a botulinum toxin type E protein sequence having proteolytic activity.
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58. A method for producing a soluble recombinant botulinum neurotoxin, comprising:
expressing an active botulinum neurotoxin from an expression vector comprising a botulinum neurotoxin nucleotide sequence that encodes a botulinum neurotoxin having a proteolytic activity, and a solubility tag. - View Dependent Claims (59, 60, 61, 62)
Specification