Clozapine and Cocaine Effects on Dopamine and Serotonin Release in Nucleus Accumbens During Psychostimulant Behavior and Withdrawal

• US 20070270403A1
• Filed: 12/06/2004
• Published: 11/22/2007
• Est. Priority Date: 12/04/2003
• Status: Abandoned Application

• Current Assignee: City College of New York
• Original Assignee: City College of New York
• Inventors: Broderick, Patricia
• Application Number:
  US10/580,884
• Publication Number:
  US 20070270403A1
• Time in Patent Office: Days
• US Class Current: 514/211.130
• CPC Class Codes: A61K 31/4515 having a butyrophenone group in position 1, e.g. haloperidol pipamperone A61K31/4545
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/5415 ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• CPC Class Codes: A61K 31/551 having two nitrogen atoms, e.g. dilazep
• CPC Class Codes: A61K 31/5513 1,4-Benzodiazepines, e.g. diazepam or clozapine
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

The present invention provides methods of treating cocaine-induced pyschosis by administering an atypical antipsychotic compound in an amount sufficient to increase serotonin concentration in the nucleus accumbens of a mammal. According to the invention, atypical antipsychotic compounds include, without limitation, clozapine, risperidone, olanzepine, quetiapine, ziprasidone, sertindole, ketanserin, aripiprazole, and haloperidol, flupenthixol, thiroridazine, loxapine, fluspirilense, and sulpliride. The invention further provides methods for microvoltammetric imaging of changes in neurotransmitter concentrations in vivo and in real time comprising contacting the cell, cells, tissue, tissues, or organ of interest with a BRODERICK PROBE® sensor, applying a potential to said BRODERICK PROBE® sensor, and monitoring a temporally and spacially resolved recording using neuromolecular imaging (NMI) and electrochemical circuits such as, for example, voltammetry. In one embodiment of the invention, neuromolecular imaging may be performed before, during or after cocaine administration and/or cocaine-induced psychosis.

Claims

1. A method of treating cocaine-induced psychosis in a mammal comprising administering an atypical antipsycotic compound to said mammal in an amount sufficient to increase serotonin concentration in the nucleus accumbens of said mammal'"'"'s brain.

2. The method of claim 1, wherein the antipsychotic compound is selected from the group consisting of clozapine, risperidone, olanzepine, quetiapine, ziprasidone, sertindole, ketanserin, aripiprazole, and haloperidol, flupenthixol, thioridazine, loxapine, fluspirilene, and sulpiride.

3. The method of claim 1, wherein the antipsychotic compound is clozapine.

4. A method of increasing the concentration of serotonin in the nucleus accumbens of a mammalian brain during or following cocaine-induced psychosis comprising administering a serotonin-increasing amount of an atypical antipsychotic compound.

5. The method of claim 4, wherein the antipsychotic compound is selected from the group consisting of clozapine, risperidone, olanzepine, quetiapine, ziprasidone, sertindole, ketanserin, aripiprazole, and haloperidol, flupenthixol, thioridazine, loxapine, fluspirilene, and sulpiride.

6. The method of claim 4, wherein the antipsychotic compound is clozapine.