Radiopaque compositions, articles and methods of making and using same

• US 20070270691A1
• Filed: 05/19/2006
• Published: 11/22/2007
• Est. Priority Date: 05/19/2006
• Status: Abandoned Application

• Current Assignee: Upchurch Scientific, Inc.
• Original Assignee: Upchurch Scientific, Inc.
• Inventors: Bailey, Michael L., Swett, James E.
• Application Number:
  US11/437,763
• Publication Number:
  US 20070270691A1
• Time in Patent Office: Days
• US Class Current: 600/431
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: A61C 2201/005 using radio-opaque means
• CPC Class Codes: A61L 17/04 Non-resorbable materials
• CPC Class Codes: A61L 27/025 Other specific inorganic materials not covered by A61L27/04 - A61L27/12
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61L 31/028 Other inorganic materials not covered by A61L31/022 - A61L31/026
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C08L 71/00 Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers

Abstract

A radiopaque composition and implant comprising a mixture of a polymer, such as polyetherketone (PEEK), polyetherketone (PEK), polyetherketoneketone (PEKK), polyetherimide, or polyphenylsulfone, and bismuth trioxide (BiO₃) is provided. The mixture comprises BiO₃ of about twenty to thirty percent (20% to 30%) by weight. The composition is useful in radiopaque implants for mammals including humans, such as in catheters, stents, screws, anchors, dental caps and posts, bone and joint replacements, and the like. The composition is also useful for radiopaque markers in implants and for radiopaque articles used in surgical and other in vivo procedures. The radiopaque items can be easily identified and located in a patient'"'"'s body via X-ray examination or fluoroscopy.

Claims

1. An implant for a mammal comprising an object comprising polyetheretherketone (PEEK) and at least ten percent (10%) by weight bismuth trioxide (BiO₃).

2. The implant according to claim 1 wherein the mammal comprises a human being.

3. The implant according to claim 1 wherein the implant further comprises at least about twenty percent (20%) by weight BiO₃.

4. The implant according to claim 1 wherein the implant further comprises about thirty percent (30%) by weight BiO₃.

5. The implant according to claim 3 wherein said implant comprises a spinal cage.

6. The implant according to claim 4 wherein said implant comprises a spinal cage.

7. The implant according to claim 3 wherein said implant comprises a screw.

8. The implant according to claim 4 wherein said implant comprises a screw.

9. The implant according to claim 3 wherein said implant comprises a dental device.

10. The implant according to claim 9 wherein the dental device comprises a filling of a tooth.

11. The implant according to claim 1 wherein said implant is a long term implant.

12. The implant according to claim 4 wherein said implant is a long term implant.

13. The implant according to claim 1 wherein said implant comprises a radiopaque marker.

14. An implant for a mammal comprising an item comprising BiO₃ and one or more polymers selected from the group consisting of polyetheretherketone, polyetherketone, polyetherketoneketone, polyphenylsulfone, and polyetherimide, wherein said implant comprises BiO₃ in an amount of between about twenty percent (20%) to thirty percent (30%) by weight.

15. The implant according to claim 14 wherein the mammal comprises a human.

16. The implant according to claim 14 wherein said polymer comprises PEEK.

17. The implant according to claim 16 wherein said implant comprises about thirty percent by (30%) weight BiO₃.

18. A medical device comprising at least ten percent (10%) by weight bismuth trioxide (BiO₃) and one or more polymers selected from the group consisting of polyetheretherketone, polyetherketone, polyetherketoneketone, polyphenlysulfone, and polyetherimide.

19. The medical device according to claim 18 wherein the device comprises a stent.

20. The medical device according to claim 18 wherein the device comprises a catheter.

21. The medical device according to claim 18 wherein the medical device comprises a screw.

22. The medical device according to claim 18 wherein the medical device comprises a suture.

23. The medical device according to claim 19 wherein the device comprises at least about twenty percent (20%) by weight BiO₃.

24. The medical device according to claim 19 wherein the device comprises from about twenty percent (20%) to about thirty percent (30%) by weight BiO₃.

25. The medical device according to claim 20 wherein the catheter comprises at least about twenty percent (20%) by weight BiO₃.

26. The medical device according to claim 20 wherein the catheter comprises from about twenty percent (20%) to about thirty percent (30%) by weight BiO₃.

27. The medical device according to claim 21 wherein the screw comprises at least about twenty percent (20%) by weight BiO₃.

28. The medical device according to claim 21 wherein the screw comprises from about twenty percent (20%) to about thirty percent (30%) by weight BiO₃.

29. A medical device comprising polytetrafluoroethylene (PTFE) and at least ten percent (10%) by weight bismuth trioxide (BiO₃).

30. The medical device according to claim 29 wherein said device comprises a portion made by paste extrusion.

31. The medical device according to claim 29 wherein said device comprises an implant for a mammal.