Transdermal Delivery System for Cosmetic Agents

• US 20070270732A1
• Filed: 06/23/2004
• Published: 11/22/2007
• Est. Priority Date: 06/23/2003
• Status: Active Grant

• Current Assignee: Syneron Medical Limited (Syneron Incorporated)
• Original Assignee: TransPharma Medical Ltd. (Syneron Incorporated)
• Inventors: Sacks, Hagit, Levin, Galit, Rudaev, Sergey
• Granted Patent: US 8,016,810 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61N 1/0424 Shape of the electrode
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/06 for countering cellulitis
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

An intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject, is useful in treating skin conditions such as cellulite, hyper-pigmentation, skin aging, and acne.

Claims

1. A system for intradermal or transdermal delivery of a water-soluble, poorly water-soluble, or water-insoluble cosmetic agent comprising:

an apparatus for facilitating intradermal or transdermal delivery of a cosmetic agent through the skin of a subject, said apparatus capable of generating at least one micro-channel in a region on the skin of the subject, and a cosmetic or dermatological composition comprising at least one water-soluble, poorly water-soluble, or water-insoluble cosmetic agent and a cosmetically or dermatologically acceptable carrier.

2. The system according to claim 1, wherein the apparatus for facilitating intradermal or transdermal delivery of a cosmetic agent through skin of a subject comprises:

a. an electrode cartridge comprising a plurality of electrodes; and

b. a main unit comprising a control unit which is adapted to apply electrical energy between two or more electrodes when the electrodes are in vicinity of the skin, generating current flow or one or more sparks, enabling ablation of stratum corneum in an area beneath the electrodes, thereby generating at least one micro-channel.

3. The system according to claim 2 wherein the electrode cartridge is removable.

4. The system according to claim 2, wherein the electrical energy is of radio frequency.

5. The system according to claim 1, wherein the cosmetic agent is selected from the group consisting of xanthines, retinoids, α

-hydroxy acids, β

-hydroxy acids, α

-2 adrenergic inhibitors, β

-adrenergic agonists, aromatase inhibitors, anti-estrogens, hydroquinone, ascorbic acid, kojic acid, corticosteroids, mucopolysaccharides, collagen, estrogens, isoflavonoids, cinnamic acid, benzoyl peroxide, tropolone, catechol, mercaptoamine, niacinamide, tocopherol, ferulic acid, azelaic acid, botulinum, urea, a derivative or salt thereof.

6. The system according to claim 5, wherein the xanthine is caffeine.

7. The system according to claim 5, wherein the β

-hydroxy acid is salicylic acid.

8. The system according to claim 5, wherein the cosmetic agent is hydroquinone.

9. The system according to claim 1, wherein the cosmetic or dermatological composition further comprising at least one component selected from the group consisting of surfactants, humectants, preservatives, antioxidants, powders, clarifying agents, coloring agents, opacifiers, thickeners, and perfumes.

10. The system according to claim 1, wherein the cosmetic or dermatological composition further comprising a pharmaceutical agent.

11. The system according to claim 10, wherein the pharmaceutical agent is an antibacterial agent.

12. The system according to claim 1, wherein the cosmetic or dermatological composition is formulated in a form selected from the group consisting of anhydrous compositions, aqueous solutions, aqueous suspensions, oil-in-water emulsions, water-in-oil emulsions, oily droplets in aqueous solutions, micelles, liposomes, ethosomes, and aqueous suspensions of nanoparticles.

13. The system according to claim 1, wherein the cosmetic or dermatological composition is in a form selected from the group consisting of lotions, creams, ointments, gels, pastes, sprays, foams, sticks, and skin patches.

14. A method for treating a skin condition in a subject comprising the steps of:

(i) generating at least one micro-channel in a region of skin of a subject suffering from a skin condition; and

(ii) topically applying a dermatologically effective amount of a cosmetic or dermatological composition comprising at least one water-soluble, poorly water-soluble, or water-insoluble cosmetic agent and a cosmetically or dermatologically acceptable carrier to the region of the skin in which the at least one micro-channel is present so as to improve the skin condition of said subject.

15. The method according to claim 14, wherein the cosmetic agent is selected from the group consisting of xanthines, retinoids, α

-hydroxy acids, β

-hydroxy acids, α

-2 adrenergic inhibitors, β

-adrenergic agonists, aromatase inhibitors, anti-estrogens, hydroquinone, ascorbic acid, kojic acid, corticosteroids, mucopolysaccharides, collagen, estrogens, isoflavonoids, cinnamic acid, benzoyl peroxide, tropolone, catechol, mercaptoamine, niacinamide, tocopherol, ferulic acid, azelaic acid, botulinum, urea, a derivative or salt thereof.

16. The method of claim 15, wherein the xanthine is caffeine.

17. The method according to claim 15, wherein the β

-hydroxy acid is salicylic acid.

18. The method according to claim 15, wherein the cosmetic agent is hydroquinone.

19. The method according to claim 14, wherein the cosmetic or dermatological composition further comprising at least one component selected from the group consisting of surfactants, humectants, preservatives, antioxidants, powders, clarifying agents, coloring agents, opacifiers, thickeners, and perfumes.

20. The method according to claim 14, wherein the cosmetic or dermatological composition further comprising a pharmaceutical agent.

21. The method according to claim 20, wherein the pharmaceutical agent is an antibacterial agent.

22. The method according to claim 14, wherein the cosmetic or dermatological composition is formulated in a form selected from the group consisting of anhydrous compositions, aqueous solutions, aqueous suspensions, oil-in-water emulsions, water-in-oil emulsions, oily droplets in aqueous solutions, micelles, liposomes, ethosomes, and aqueous suspensions of nanoparticles.

23. The method according to claim 14, wherein the cosmetic or dermatological composition is in a form selected from the group consisting of lotions, creams, ointments, gels, pastes, sprays, foams, sticks, and skin patches.

24. The method according to claim 14, wherein the skin condition is selected from cellulite, acne vulgaris, acne cystic, skin aging, skin wrinkles, hyperpigmentation, keratosis, skin blemish, dandruff, warts, photodamaged skin, chronic dermatoses, dermatitis, dryness, ichthyosis, viral infections, fungal infections, and bacterial skin infections.