Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
First Claim
1. An implantable medical device for controlled drug delivery comprising:
- an elongated body dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein the elongated body portion comprises a first, closed end portion, a second, closed end portion and an intermediate portion disposed between and connected to the first closed end portion and the second closed end portion;
two or more discrete reservoirs disposed in the elongated body portion, each reservoir having one or more openings;
a drug formulation, which comprises at least one drug, disposed in the two more discrete reservoirs; and
reservoir caps closing off the one or more openings of each reservoir,wherein release of the drug in vivo is controlled at least in part by the in vivo disintegration or permeabilization of the discrete reservoir caps.
1 Assignment
0 Petitions
Accused Products
Abstract
Implantable medical devices and methods of use are provided for controlled drug delivery. The devices may include an elongated body dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein the elongated body portion comprises a first, closed end portion, a second closed end portion and an intermediate portion disposed between and connected to the first closed end portion and the second closed end portion; two or more discrete reservoirs disposed in the elongated body portion, each reservoir having one or more openings; a drug formulation, which comprises at least one drug, disposed in the two more discrete reservoirs; and reservoir caps closing off the one or more openings of each reservoir, wherein release of the drug in vivo is controlled at least in part by the in vivo disintegration or permeabilization of the discrete reservoir caps.
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Citations
31 Claims
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1. An implantable medical device for controlled drug delivery comprising:
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an elongated body dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein the elongated body portion comprises a first, closed end portion, a second, closed end portion and an intermediate portion disposed between and connected to the first closed end portion and the second closed end portion; two or more discrete reservoirs disposed in the elongated body portion, each reservoir having one or more openings; a drug formulation, which comprises at least one drug, disposed in the two more discrete reservoirs; and reservoir caps closing off the one or more openings of each reservoir, wherein release of the drug in vivo is controlled at least in part by the in vivo disintegration or permeabilization of the discrete reservoir caps. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 27, 28, 29, 30, 31)
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19. An implantable medical device for controlled drug delivery comprising,
a first solid unit of a drug formulation which comprises at least one drug, the first solid unit have a proximal end, a distal end, and one or more longitudinal exterior surfaces therebetween; -
a second solid unit of the drug formulation which comprises the at least one drug, the second solid unit have a proximal end, a distal end, and one or more longitudinal exterior surfaces therebetween; a layer of a first membrane material coating the longitudinal exterior surfaces of the first solid unit; a layer of a second membrane material coating the longitudinal exterior surfaces of the second solid unit; and a substantially impermeable seal member sandwiched between the proximal end of the first solid unit and the distal end of the second solid unit, such that the first solid unit, seal member, and second solid unit are connected together aligned in an elongated rod shaped form, which is dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein release of the drug in vivo is controlled at least in part by the in viva disintegration or permeabilization of the first and second membrane materials. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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Specification