Preparation Method for Sustained Release Microspheres Using a Dual-Feed Nozzle
First Claim
1. A method of preparing sustained release microspheres encapsulating a drug in a biodegradable polymer carrier, comprising:
- (a) preparing two different liquids for preparation of the sustained release microspheres comprising a biodegradable polymer, a drug, an additive and a solvent with different compositions for one or more of the components;
(b) simultaneously spraying the two different liquids through internal and external channels of an ultrasonic dual-feed nozzle, wherein one liquid is supplied through the internal channel and another liquid is supplied through the external channel, and the liquid supplied through the external channel does not contain water; and
(c) evaporating the solvent using dry air to dry sprayed droplets.
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Abstract
Disclosed is a method of preparing sustained release microspheres by spray-drying liquids with different compositions for preparation the sustained release microspheres through an ultrasonic dual-feed nozzle. Unlike conventional methods of preparing sustained release microspheres by spray-drying a single liquid containing a biodegradable polymer, a drug, an additive and a solvent through a single-feed nozzle, the present method is characterized by simultaneously spray-drying two liquids with different compositions for preparation of the sustained release microspheres respectively through internal and external channels of an ultrasonic dual-feed nozzle to coat sprayed droplets through the internal channel with other sprayed droplets through the external channel. The present method is effective in achieving a low initial release and a desired continuous release.
28 Citations
7 Claims
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1. A method of preparing sustained release microspheres encapsulating a drug in a biodegradable polymer carrier, comprising:
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(a) preparing two different liquids for preparation of the sustained release microspheres comprising a biodegradable polymer, a drug, an additive and a solvent with different compositions for one or more of the components;
(b) simultaneously spraying the two different liquids through internal and external channels of an ultrasonic dual-feed nozzle, wherein one liquid is supplied through the internal channel and another liquid is supplied through the external channel, and the liquid supplied through the external channel does not contain water; and
(c) evaporating the solvent using dry air to dry sprayed droplets. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification