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Preparation Method for Sustained Release Microspheres Using a Dual-Feed Nozzle

  • US 20070275082A1
  • Filed: 09/03/2004
  • Published: 11/29/2007
  • Est. Priority Date: 09/04/2003
  • Status: Abandoned Application
First Claim
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1. A method of preparing sustained release microspheres encapsulating a drug in a biodegradable polymer carrier, comprising:

  • (a) preparing two different liquids for preparation of the sustained release microspheres comprising a biodegradable polymer, a drug, an additive and a solvent with different compositions for one or more of the components;

    (b) simultaneously spraying the two different liquids through internal and external channels of an ultrasonic dual-feed nozzle, wherein one liquid is supplied through the internal channel and another liquid is supplied through the external channel, and the liquid supplied through the external channel does not contain water; and

    (c) evaporating the solvent using dry air to dry sprayed droplets.

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