Conversion Of Sea-Shells And Other Calcite-Based And Aragonite-Based Materials With Dense Structures Into Synthetic Materials For Implants And Other Structures And Devices

• US 20070275088A1
• Filed: 08/13/2007
• Published: 11/29/2007
• Est. Priority Date: 02/11/2005
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Vecchio, Kenneth
• Application Number:
  US11/838,181
• Publication Number:
  US 20070275088A1
• Time in Patent Office: Days
• US Class Current: 424/548
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00341 Coral, e.g. aragonite, porite
• CPC Class Codes: A61F 2310/00347 Nacre or mother-of-pearl
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel

Abstract

Bulk materials for implants and scaffolds made from hydrothermal conversion of bulk calcium carbonate materials with desired initial structures in order to utilize the mechanical and structural properties of the initial structures. Dense sea-shells, light-weighted sea urchin spines and strong marine bones such as cuttlebones are examples of bulk calcium carbonate materials with desired initial structures for producing various implants and scaffolds.

Claims

1. An implant fabrication method, comprising:

using a bulk calcium carbonate material in a dense structure to contact ammonium phosphate in a water solution; and

heating the bulk calcium carbonate material and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce a bulk dense hydroxyapatite material.

2. The method as in claim 1, further comprising applying a pressure greater than the atmosphere pressure to the bulk calcium carbonate material and the ammonium phosphate in the water solution.

3. The method as in claim 1, wherein the bulk calcium carbonate material is a sea shell.

4. The method as in claim 3, wherein the sea shell is a conch shell, a clam shell, or a abalone shell.

5. An implant fabrication method, comprising:

using a piece of bulk marine bone to contact ammonium phosphate in a water solution; and

heating the bulk marine bone and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce a bulk hydroxyapatite material.

6. The method as in claim 5, wherein the piece of marine bone is a piece of cuttlebone.

7. An implant material, comprising a bulk hydroxyapatite material, which is produced by a process of:

contacting a bulk calcium carbonate material in a dense structure of a natural material with ammonium phosphate in a water solution, and

heating the bulk calcium carbonate material and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce the bulk hydroxyapatite material,

wherein the bulk calcium carbonate is a bulk sea shell piece or a bulk piece of marine bone.

8. An implant fabrication method, comprising:

contacting a bulk piece of a sea urchin spine with ammonium phosphate in a water solution; and

heating the sea urchin spine and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce a bulk beta-tricalcium phosphate material.

9. The method as in claim 8, further comprising applying a pressure greater than the atmosphere pressure to the sea urchin spine and the ammonium phosphate in the water solution.

10. An implant material, comprising a bulk beta-tricalcium phosphate material, which is produced by a process of:

contacting a bulk piece of a sea urchin spine with ammonium phosphate in a water solution, and

heating the sea urchin spine and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce the bulk beta-tricalcium phosphate material.

11. The material as in claim 10, wherein the process further comprises:

applying a pressure greater than the atmosphere pressure to the sea urchin spine and the ammonium phosphate in the water solution.

12. An implant, comprising a bulk beta-tricalcium phosphate material produced from a bulk natural marine material by a hydrothermal conversion process.

13. The implant as in claim 12, wherein the conversion comprises:

contacting the bulk natural marine material with ammonium phosphate in a water solution, and

heating the bulk natural marine material and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce the bulk beta-tricalcium phosphate material.

14. The implant as in claim 13, wherein the bulk natural marine material includes a sea urchin spine.

15. An implant, comprising a dense hydroxyapatite material converted from a bulk natural marine material by a hydrothermal conversion process.

16. The implant as in claim 15, wherein the conversion comprises:

contacting the bulk natural marine material with ammonium phosphate in a water solution, and

heating the bulk natural marine material and the ammonium phosphate in the water solution to a temperature from about 150°

C. to about 250°

C. to produce the dense hydroxyapatite material.

17. The implant as in claim 16, wherein the bulk natural marine material includes a bulk piece of a sea shell.

18. A method for transferring cells to a patient, comprising:

planting cells harvested from a patient onto a bulk dense hydroxyapatite material substrate to grow and replicate the cells in vitro, wherein the bulk dense hydroxyapatite material substrate is synthesized from a bulk calcium carbonate material in a dense structure by contacting ammonium phosphate in a water solution in a hydrothermal process;

removing the cells from the bulk dense hydroxyapatite material substrate; and

surgically planting the removed cells into the patient.

19. The method as in claim 18, wherein:

the cells are chondrocyte cells.