METHOD OF AFFECTING SLEEP AND SLEEP-RELATED BEHAVIORS
First Claim
1. A method of affecting sleep and sleep-related behaviors in a mammal having a diurnal rhythm, said method comprising administering a sensory regimen to said mammal on at least four consecutive days, said sensory regimen comprising:
- subjecting said mammal to a combination of an olfactory stimuli, an auditory stimuli, and a visual stimuli, for a first period of about 5 minutes, at about 30 minutes after morning waking, subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a second period of about 5 minutes, at about 4 hours after waking subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a third period of about 5 minutes, at about 8 hours after waking; and
subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a fourth period of about 15 minutes, prior to bedtime of said mammal, wherein said mammal is further subjected to a tactile stimuli during said fourth period, wherein the HPA axis of said mammal is reduced.
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Abstract
A method of affecting sleep and sleep-related behaviors of a mammal having a diurnal rhythm, by reducing the basal activity of the hypothalamus-pituitary-adrenal axis by administering an effective amount of a sensory regimen is disclosed. Such reduction may be accomplished by reducing at least one of the following: a. the average total daily amount of adrenocortical hormone; or b. the average total daily amount adrenocortical hormone minus the integrative measure of morning peak adrenocortical hormone. Preferably, such reduction also includes reducing at least one of the following: c. the level of adrenocortical hormone 4 hours to 8 hours after waking; d. the level of adrenocortical hormone in the period of time preceding bedtime; or e. the level of adrenocortical hormone below the onset of sleep threshold.
56 Citations
17 Claims
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1. A method of affecting sleep and sleep-related behaviors in a mammal having a diurnal rhythm, said method comprising administering a sensory regimen to said mammal on at least four consecutive days, said sensory regimen comprising:
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subjecting said mammal to a combination of an olfactory stimuli, an auditory stimuli, and a visual stimuli, for a first period of about 5 minutes, at about 30 minutes after morning waking, subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a second period of about 5 minutes, at about 4 hours after waking subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a third period of about 5 minutes, at about 8 hours after waking; and
subjecting said mammal to said combination of said olfactory stimuli, said auditory stimuli, and said visual stimuli, for a fourth period of about 15 minutes, prior to bedtime of said mammal, wherein said mammal is further subjected to a tactile stimuli during said fourth period, wherein the HPA axis of said mammal is reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification