Methods for Treating or Ameliorating Ghrelin-Associated Diseases and Disorders
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Abstract
Methods for modulating the effective levels of ghrelin are disclosed. These methods include the use of amylin, amylin agonists and amylin antagonists to regulate the effective levels of ghrelin. Methods for the prevention, treatment, or amelioration of ghrelin-associated diseases or disorders utilizing the methods for modulating ghrelin are also disclosed.
35 Citations
23 Claims
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1-3. -3. (canceled)
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5-11. -11. (canceled)
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12. A method of modulating ghrelin levels in an individual comprising administering a composition comprising an amylin, an amylin agonist, an amylin antagonist, or a compound to induce or inhibit endogenous amylin levels to an individual in need of modulating ghrelin levels in an amount effective to modulate ghrelin levels in the individual.
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13. A method of reducing ghrelin levels in an individual comprising administering to an individual in need of reducing ghrelin levels a composition comprising an amylin, an amylin agonist, or an agent that increases endogenous levels of amylin in the individual.
- 14. A method of ameliorating a disease or disorder that can benefit from a reduction in ghrelin levels comprising administering to an individual having a disease or disorder that can benefit from a reduction in ghrelin levels an effective amount of a composition comprising an amylin, an amylin agonist, or an agent that increases endogenous levels of amylin.
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19. A method of increasing ghrelin levels in an individual comprising administering to an individual in need of increased ghrelin levels a composition comprising an amylin antagonist or an agent that decreases endogenous levels of amylin in the individual.
- 20. A method of ameliorating a disease or disorder that can benefit from an increase in ghrelin levels comprising administering to an individual having a disease or disorder that can benefit from an increase in ghrelin levels an effective amount of a composition comprising an amylin antagonist or an agent that decreases endogenous levels of amylin.
Specification