Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
First Claim
1. An apparatus for determining one or more properties of in vivo tissue, comprising:
- a. an illumination system adapted to produce light at a plurality of broadband wavelength ranges;
b. an optical probe adapted to receive broadband light from the illumination system and transmit the broadband light to in vivo tissue, and to receive light diffusely reflected in response to the broadband tight, emitted from the in vivo tissue by fluorescence thereof in response to the broadband tight, or a combination thereof;
c. a calibration device which is periodically in optical communication with the optical probe d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine a property of the in vivo tissue from the spectral properties signal.
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Accused Products
Abstract
Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.
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Citations
34 Claims
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1. An apparatus for determining one or more properties of in vivo tissue, comprising:
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a. an illumination system adapted to produce light at a plurality of broadband wavelength ranges;
b. an optical probe adapted to receive broadband light from the illumination system and transmit the broadband light to in vivo tissue, and to receive light diffusely reflected in response to the broadband tight, emitted from the in vivo tissue by fluorescence thereof in response to the broadband tight, or a combination thereof;
c. a calibration device which is periodically in optical communication with the optical probe d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine a property of the in vivo tissue from the spectral properties signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An apparatus for determining a disease state of in vivo tissue, comprising;
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a. an illumination system adapted to produce a sequence of broadband ranges of light;
b. an optical probe adapted to receive broadband light from the illumination system and transmit the broadband light to in vivo tissue, and to receive light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof;
c. a calibration device which is periodically in optical communication with the optical probe d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine a disease state of the in vivo tissue from the spectral properties signal. - View Dependent Claims (30, 31, 32, 33, 34)
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16. An apparatus for determining the presence of diabetes, pre-diabetes, or both, in a human, comprising;
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a. an illumination system adapted to produce a sequence of broadband ranges of light;
b. an optical probe adapted to receive broadband tight from the illumination system and transmit the broadband light to in vivo tissue of the human, and to receive light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof;
c. a calibration device which is periodically in optical communication with the optical probe d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine the presence of diabetes, pre-diabetes, or both, in the humen from the spectral properties signal. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification