Diagnosis and Prediction of Parkinson's Disease
First Claim
1. An in vitro method for diagnosis or prediction of Parkinson'"'"'s disease in a subject, the method comprising testing for a mutation of a mitochondrial DNA polymerase POLG1 gene (SEQ ID No. 2) of the subject and, where the mutation is detected, diagnosing or predicting Parkinson'"'"'s disease in the subject.
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Abstract
The present invention provides an in vitro method for diagnosis or prediction of Parkinson'"'"'s disease in a subject, the method comprising testing for a mutation of a mitochondrial DNA polymerase POLG1 gene of the subject and, where the mutation is detected, diagnosing or predicting Parkinson'"'"'s disease in the subject. Further, the present invention provides a diagnostic kit for diagnosis or prediction of Parkinson'"'"'s disease in a subject.
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Citations
32 Claims
- 1. An in vitro method for diagnosis or prediction of Parkinson'"'"'s disease in a subject, the method comprising testing for a mutation of a mitochondrial DNA polymerase POLG1 gene (SEQ ID No. 2) of the subject and, where the mutation is detected, diagnosing or predicting Parkinson'"'"'s disease in the subject.
- 17. A diagnostic kit for diagnosis or prediction of Parkinson'"'"'s disease in a subject, comprising means for testing for a mutation of the POLG1 gene of the subject and means for determining whether the mutation is indicative for Parkinson'"'"'s disease.
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19. (canceled)
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21. (canceled)
- 22. An isolated polynucleotide comprising at least one mutation of the POLG1 gene, or a fragment of said polynucleotide.
Specification