Ion mobility spectrometry waveform
First Claim
Patent Images
1. An apparatus for separating ions, comprising:
- (a) an analyzer region comprising an inner electrode and an outer electrode, the inner electrode having an inner electrode external surface, the outer electrode having an outer electrode internal surface and a central region, wherein the inner electrode is disposed in the central region of the outer electrode forming a non-uniform gap between the inner electrode external surface and the outer electrode inner surface;
(b) a contact for applying an asymmetric waveform to one of the inner electrode and outer electrodes; and
(c) a contact for applying a compensation voltage to one of the inner electrode and the outer electrodes.
1 Assignment
0 Petitions
Accused Products
Abstract
A high-field asymmetric waveform ion mobility spectrometer (FAIMS) with enhanced ion focusing is provided. The apparatus comprises an outer electrode with a central region and inner surface and an inner electrode disposed in the central region of the outer electrode. The inner and outer electrodes are positioned to form a non-uniform gap between the inner electrode and outer electrode inner surface. A method of using the apparatus to analyze ionized samples is also provided.
-
Citations
21 Claims
-
1. An apparatus for separating ions, comprising:
-
(a) an analyzer region comprising an inner electrode and an outer electrode, the inner electrode having an inner electrode external surface, the outer electrode having an outer electrode internal surface and a central region, wherein the inner electrode is disposed in the central region of the outer electrode forming a non-uniform gap between the inner electrode external surface and the outer electrode inner surface; (b) a contact for applying an asymmetric waveform to one of the inner electrode and outer electrodes; and (c) a contact for applying a compensation voltage to one of the inner electrode and the outer electrodes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A high field asymmetric waveform ion mobility spectrometer comprising:
-
(a) an ion source; (b) an analyzer region adjacent the ion source;
the analyzer region comprising;
(i) an inner electrode having an external surface and an inner electrode center axis and a hollow outer electrode having an inner surface, a central region and an outer electrode center axis, wherein the inner electrode is disposed in the central region of the hollow outer electrode and the center axis of inner electrode and the center axis the outer electrode are parallel and non-coincident, thereby forming a non-uniform gap between the inner electrode external surface and the hollow outer electrode inner surface, a contact for applying an asymmetric waveform to the inner electrode, and a contact for applying a compensation voltage to the hollow outer electrode; and(c) a detector adjacent the analyzer region. - View Dependent Claims (12, 13, 14, 15, 16)
-
-
17. A method for separating ions comprising the steps of:
-
(a) providing a plurality of ionic species; (b) providing an analyzer including an analyzer region comprising a inner electrode having an external surface and an inner electrode center axis and a hollow outer electrode having an inner surface, a central region and an outer electrode center axis and wherein the inner electrode is disposed in the central region of the hollow outer electrode and the center axis of inner electrode and the center axis the outer electrode center are parallel and non-coincident thereby forming a non-uniform gap between the inner electrode external surface and the hollow outer electrode inner surface; c) providing an asymmetric waveform to one of the inner electrode and the outer electrode to generate a high field in the non-uniform gap; d) setting the high field asymmetric waveform in order to effect a difference in net displacement between a first and a second ion species of the plurality of ion species in the time of one cycle of the applied asymmetric waveform; e) applying a compensation voltage to one of the inner electrode and the outer electrode. - View Dependent Claims (18, 19, 20, 21)
-
Specification