INTRA-OPERATIVE COATING OF IMPLANTS

• US 20070280986A1
• Filed: 06/01/2006
• Published: 12/06/2007
• Est. Priority Date: 06/01/2006
• Status: Abandoned Application

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Gil, Carlos, Samaranska, Aneta
• Application Number:
  US11/421,579
• Publication Number:
  US 20070280986A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: B29C 2035/0827 using UV radiation
• CPC Class Codes: B29C 2037/0035 the coating being applied as liquid, gel, paste or the like
• CPC Class Codes: B29C 37/0032 the coating being applied upon the mould surface before introducing the moulding compound, e.g. applying a gelcoat B29C44/14 and B29C44/32 take precedence
• CPC Class Codes: B29L 2031/7532 Artificial members, protheses
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

Embodiments described herein provide methods and systems for applying biologically-active coatings to implants. More particularly, embodiments relate to methods for intra-operative coating of implants, such as orthopedic implants, with biologically-active coatings, such as coatings containing osteoinductive and osteoconductive biological components. An embodiment provides a method for applying a biologically-active coating to an implant. Another embodiment provides a method for implanting an implant with a biologically-active coating during an operation.

Claims

1. A method for applying a biologically-active coating to an implant, comprising:

mixing together a polymerizable component and a biological component to form a polymerizable solution;

applying the polymerizable solution to the implant; and

curing the polymerizable solution;

wherein mixing, applying, and curing are carried out intra-operatively.

2. The method of claim 1, wherein the polymerizable component is selected from the group consisting of catalyst-initiated polymerizable components, redox-initiated polymerizable components, two-part polymerizable components, heat-curable polymerizable components, and radiation-curable polymerizable components.

3. The method of claim 1, wherein applying the polymerizable solution to the implant is selected from the group consisting of spraying the polymerizable solution onto the implant, pasting the polymerizable solution onto the implant, dip-coating the implant in the polymerizable solution, and curing the polymerizable solution and applying the cured polymerized solution to the implant.

4. The method of claim 1, wherein curing the polymerizable solution is selected from the group consisting of applying heat to the polymerizable solution, applying radiation to the polymerizable solution, and introducing a catalyst into the polymerizable solution.

5. The method of claim 1, wherein applying the polymerizable solution to the implant comprises pouring the polymerizable solution into a mold, press-fitting the implant into the mold, and closing the mold.

6. The method of claim 5, wherein the polymerizable solution is cured while the implant is held in the closed mold.

7. The method of claim 1, wherein the polymerizable component is a UV-polymerizable component, and curing the polymerizable solution comprises applying UV-radiation to the polymerizable solution.

8. The method of claim 1, further comprising sterilizing the polymerizable component and the biological component prior to mixing them together.

9. The method of claim 8, wherein sterilizing is carried out extra-operatively.

10. The method of claim 1, wherein the polymerizable solution forms a hydrogel upon curing.

11. The method of claim 10, wherein the hydrogel is selected from polyethylene glycol (PEG) and polyethylene glycol diacrylate (PEGDA).

12. The method of claim 1, wherein the biological component is an osteoinductive or osteoconductive component.

13. The method of claim 1, wherein the polymerizable solution is capable of being cured in less than or about 5 minutes.

14. The method of claim 1, wherein the implant is an orthopedic implant.

15. A method for implanting an implant with a biologically-active coating during an operation, comprising:

providing a sterilized polymerizable component and a sterilized biological component;

intra-operatively mixing together the polymerizable component and the biological component to form a polymerizable solution;

intra-operatively applying the polymerizable solution to the implant;

intra-operatively curing the polymerizable solution; and

implanting the implant into a patient during the course of the operation.

16. The method of claim 15, wherein the polymerizable component is selected from the group consisting of catalyst-initiated polymerizable components, redox-initiated polymerizable components, two-part polymerizable components, heat-curable polymerizable components, and radiation-curable polymerizable components.

17. The method of claim 15, wherein applying the polymerizable solution to the implant is selected from the group consisting of spraying the polymerizable solution onto the implant, pasting the polymerizable solution onto the implant, dip-coating the implant in the polymerizable solution, and curing the polymerizable solution and applying the cured polymerized solution to the implant.

18. The method of claim 15, wherein curing the polymerizable solution is selected from the group consisting of applying heat to the polymerizable solution, applying radiation to the polymerizable solution, and introducing a catalyst into the polymerizable solution.

19. The method of claim 15, wherein intra-operatively applying the polymerizable solution to the implant comprises pouring the polymerizable solution into a mold, press-fitting the implant into the mold, and closing the mold.

20. The method of claim 19, wherein the polymerizable solution is cured while the implant is held in the closed mold.

21. The method of claim 15, wherein the polymerizable component is a UV-polymerizable component, and curing the polymerizable solution comprises applying UV-radiation to the polymerizable solution.

22. The method of claim 15, wherein providing a sterilized polymerizable component and a sterilized biological component comprises extra-operatively sterilizing the polymerizable component and the biological component.

23. The method of claim 15, wherein the polymerizable solution forms a hydrogel upon curing.

24. The method of claim 23, wherein the hydrogel is selected from polyethylene glycol (PEG) and polyethylene glycol diacrylate (PEGDA).

25. The method of claim 15, wherein the biological component is an osteoinductive or osteoconductive component.

26. The method of claim 15, wherein the polymerizable solution is capable of being cured in less than or about 5 minutes.

27. The method of claim 15, wherein the implant is an orthopedic implant.