Nanoparticulate posaconazole formulations
First Claim
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1. A stable nanoparticulate posaconazole composition comprising:
- (a) particles of a posaconazole or a salt or derivative thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer.
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Abstract
The invention is directed to compositions comprising a nanoparticulate posaconazole, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate posaconazole particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the prevention and treatment of fungal infection and related diseases. The posaconazole particles may be formulated as a parenteral dosage form.
144 Citations
26 Claims
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1. A stable nanoparticulate posaconazole composition comprising:
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(a) particles of a posaconazole or a salt or derivative thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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- 22. A method for preparing a nanoparticulate posaconazole, or a salt or derivative thereof, composition comprising contacting posaconazole particles with at least one surface stabilizer for a time and under conditions sufficient to provide a nanoparticulate posaconazole composition having an effective average particle size of less than about 2000 nm.
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25. A method for preventing and/or treating a fungal infection or related disease comprising administering a nanoparticulate posaconazole composition comprising:
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(a) particles of a posaconazole or a salt or derivative thereof having an effective average particle size of less than about 2000 nm; and
(b) at least one surface stabilizer. - View Dependent Claims (26)
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Specification