COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS
First Claim
1. A method of inhibiting growth of cancer cells expressing the hedgehog signaling pathway comprising, contacting the cells with effective amounts of a hedgehog inhibitor and a chemotherapeutic agent to inhibit the growth of the cells.
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Abstract
The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
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Citations
41 Claims
- 1. A method of inhibiting growth of cancer cells expressing the hedgehog signaling pathway comprising, contacting the cells with effective amounts of a hedgehog inhibitor and a chemotherapeutic agent to inhibit the growth of the cells.
- 16. A method of enhancing the antiproliferative effect of chemotherapy in a mammalian patient comprising, co-administering to the patient therapeutically effective amounts of a hedgehog inhibitor and a chemotherapeutic agent to enhance the antiproliferative effect of the chemotherapy.
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18. A method of inhibiting abnormal growth of cells expressing the hedgehog signaling pathway in a mammalian patient comprising, co-administering therapeutically effective amounts of a hedgehog inhibitor and a chemotherapeutic agent to inhibit the abnormal growth of the cells.
- 19. A method of inhibiting or reducing the growth of a tumor in a mammalian patient comprising, co-administering therapeutically effective amounts of a hedgehog inhibitor and a chemotherapeutic agent wherein the co-administration inhibits or reduces the ability of the tumor to grow.
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22. A therapeutic combination for inhibiting or reducing the proliferation of cancerous cells expressing the hedgehog signaling pathway comprising effective amounts of a hedgehog inhibitor and a chemotherapeutic agent to inhibit or reduce the proliferation of the cancerous cells.
- 23. A method of inhibiting the proliferation of cancerous cells expressing the hedgehog signaling pathway comprising, contacting the cells with therapeutically effective amounts of a hedgehog inhibitor and a chemotherapeutic agent, and an effective dose of radiation to inhibit or reduce the proliferation of the cells.
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35. A therapeutic combination for inhibiting or reducing the proliferation of cancerous cells expressing the hedgehog signaling pathway comprising therapeutically effective amounts of a hedgehog inhibitor and a chemotherapeutic agent, and an effective dose of radiation to inhibit or reduce the proliferation of the cells.
- 36. A method of inhibiting or reducing the proliferation of cancerous cells expressing the hedgehog signaling pathway comprising, contacting the cells with or introducing into the cells an effective amount of a hedgehog inhibitor and an effective dose of radiation to inhibit or reduce the proliferation of the cells.
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41. A therapeutic combination for inhibiting or reducing the proliferation of cancerous cells comprising an effective amount of a hedgehog inhibitor and an effective dose of radiation to inhibit or reduce the proliferation of the cells.
Specification